C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD74 molecule, major histocompatibility complex, class II invariant chain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000019582 CD74 9606 - 5:150401637-150412929 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000009530 CD74-003 150402152-150412751 protein_coding
  ENST00000353334 CD74-001 150401670-150412929 protein_coding
  ENST00000377795 CD74-002 150401637-150412769 protein_coding
  ENST00000517752 CD74-013 150404486-150412746 retained_intron
  ENST00000517791 CD74-005 150406039-150412912 retained_intron
  ENST00000518797 CD74-004 150401699-150412732 protein_coding
  ENST00000522153 CD74-010 150406705-150412751 retained_intron
  ENST00000522246 CD74-009 150404664-150412751 nonsense_mediated_decay
  ENST00000523208 CD74-008 150402170-150412739 nonsense_mediated_decay
  ENST00000523813 CD74-007 150405316-150412751 nonsense_mediated_decay
  ENST00000523836 CD74-006 150405978-150412751 retained_intron
  ENST00000524315 CD74-011 150401864-150412751 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000009530ENST00000353334ENST00000377795ENST00000522246
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000009530 249.972±0.00 N/A N/A 86.209±0.00 222.884±0.00 43.910±29.42 N/A N/A N/A 580.258±0.00 46.317±0.00 N/A 98.228±0.56 99.762±0.00
ENST00000353334 177.088±0.00 N/A 38.671±0.00 26.787±13.22 103.936±43.36 39.094±1.61 80.806±61.21 215.702±148.76 33.413±2.03 534.008±390.71 37.764±19.38 188.922±117.70 211.645±21.77 65.827±12.54
ENST00000377795 525.752±0.00 1592.660±0.00 30.709±0.00 130.950±101.05 358.806±322.58 118.566±79.26 110.360±102.92 354.111±310.99 56.142±8.55 2021.860±0.00 83.946±42.15 211.978±155.00 311.893±19.24 394.247±0.00
ENST00000522246 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 175.875±0.00 202.479±0.00 35.889±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00091Q CIL_00091Q_0001 VISTA 5:150006686-150608670

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0000187 IEA activation of MAPK activity
GO:0001516 IDA prostaglandin biosynthetic process
GO:0001540 IPI beta-amyloid binding
GO:0001961 IMP positive regulation of cytokine-mediated signaling pathway
GO:0002606 IEA positive regulation of dendritic cell antigen processing and presentation
GO:0002792 IDA negative regulation of peptide secretion
GO:0002830 IEA positive regulation of type 2 immune response
GO:0002906 IEA negative regulation of mature B cell apoptotic process
GO:0004896 IDA cytokine receptor activity
GO:0005515 IPI protein binding
GO:0005622 TAS intracellular
GO:0005764 IEA lysosome
GO:0005765 TAS lysosomal membrane
GO:0005770 IEA late endosome
GO:0005771 IEA multivesicular body
GO:0005773 IDA vacuole
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0006461 ISS protein complex assembly
GO:0006886 ISS:IEA intracellular protein transport
GO:0006952 IEA defense response
GO:0006955 IEA immune response
GO:0007165 IDA signal transduction
GO:0008283 IDA cell proliferation
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA:IEA membrane
GO:0016021 IDA integral component of membrane
GO:0016064 ISS immunoglobulin mediated immune response
GO:0019882 IEA antigen processing and presentation
GO:0019883 NAS antigen processing and presentation of endogenous antigen
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019955 IPI cytokine binding
GO:0023026 IDA MHC class II protein complex binding
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0030890 IMP positive regulation of B cell proliferation
GO:0032588 TAS trans-Golgi network membrane
GO:0035691 IEA macrophage migration inhibitory factor signaling pathway
GO:0035692 IDA macrophage migration inhibitory factor receptor complex
GO:0035693 IEA NOS2-CD74 complex
GO:0035718 IPI macrophage migration inhibitory factor binding
GO:0042289 ISS:IEA MHC class II protein binding
GO:0042613 ISS MHC class II protein complex
GO:0042658 IDA MHC class II protein binding, via antigen binding groove
GO:0042802 TAS identical protein binding
GO:0043030 NAS regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0043202 TAS lysosomal lumen
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044183 IDA protein binding involved in protein folding
GO:0045058 NAS T cell selection
GO:0045059 IEA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0045581 IEA negative regulation of T cell differentiation
GO:0045582 IEA positive regulation of T cell differentiation
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050998 IEA nitric-oxide synthase binding
GO:0051085 IEA chaperone mediated protein folding requiring cofactor
GO:0060907 ISS positive regulation of macrophage cytokine production
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:0090023 ISS positive regulation of neutrophil chemotaxis
GO:1902166 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 ISS positive regulation of chemokine (C-X-C motif) ligand 2 production

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009087 cd74a CD74 molecule, major histocompatibility complex, class II invariant chain a protein_coding Danio_rerio
ENSMUSG00000024610 Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) protein_coding Mus_musculus

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