C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: CD74 molecule, major histocompatibility complex, class II invariant chain
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000009530 CD74-003 ENSG00000019582 9606 - 5:150402152-150412751 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonLungMusclePlacentaTestisENST00000009530
Transcript ID Adipose Brain Breast Colon Lung Muscle Placenta Testis
ENST00000009530 249.972±0.00 86.209±0.00 222.884±0.00 43.910±29.42 580.258±0.00 46.317±0.00 98.228±0.56 99.762±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00091Q CIL_00091Q_0001 VISTA 5:150006686-150608670

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0000187 IEA activation of MAPK activity
GO:0001516 IDA prostaglandin biosynthetic process
GO:0001540 IPI beta-amyloid binding
GO:0001961 IMP positive regulation of cytokine-mediated signaling pathway
GO:0002606 IEA positive regulation of dendritic cell antigen processing and presentation
GO:0002792 IDA negative regulation of peptide secretion
GO:0002830 IEA positive regulation of type 2 immune response
GO:0002906 IEA negative regulation of mature B cell apoptotic process
GO:0004896 IDA cytokine receptor activity
GO:0005515 IPI protein binding
GO:0005622 TAS intracellular
GO:0005764 IEA lysosome
GO:0005765 TAS lysosomal membrane
GO:0005770 IEA late endosome
GO:0005771 IEA multivesicular body
GO:0005773 IDA vacuole
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0006461 ISS protein complex assembly
GO:0006886 ISS:IEA intracellular protein transport
GO:0006952 IEA defense response
GO:0006955 IEA immune response
GO:0007165 IDA signal transduction
GO:0008283 IDA cell proliferation
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0012507 TAS ER to Golgi transport vesicle membrane
GO:0016020 IDA:IEA membrane
GO:0016021 IDA integral component of membrane
GO:0016064 ISS immunoglobulin mediated immune response
GO:0019882 IEA antigen processing and presentation
GO:0019883 NAS antigen processing and presentation of endogenous antigen
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019955 IPI cytokine binding
GO:0023026 IDA MHC class II protein complex binding
GO:0030658 TAS transport vesicle membrane
GO:0030666 TAS endocytic vesicle membrane
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0030890 IMP positive regulation of B cell proliferation
GO:0032588 TAS trans-Golgi network membrane
GO:0035691 IEA macrophage migration inhibitory factor signaling pathway
GO:0035692 IDA macrophage migration inhibitory factor receptor complex
GO:0035693 IEA NOS2-CD74 complex
GO:0035718 IPI macrophage migration inhibitory factor binding
GO:0042289 ISS:IEA MHC class II protein binding
GO:0042613 ISS MHC class II protein complex
GO:0042658 IDA MHC class II protein binding, via antigen binding groove
GO:0042802 TAS identical protein binding
GO:0043030 NAS regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0043202 TAS lysosomal lumen
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044183 IDA protein binding involved in protein folding
GO:0045058 NAS T cell selection
GO:0045059 IEA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0045581 IEA negative regulation of T cell differentiation
GO:0045582 IEA positive regulation of T cell differentiation
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050998 IEA nitric-oxide synthase binding
GO:0051085 IEA chaperone mediated protein folding requiring cofactor
GO:0060907 ISS positive regulation of macrophage cytokine production
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:0090023 ISS positive regulation of neutrophil chemotaxis
GO:1902166 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 ISS positive regulation of chemokine (C-X-C motif) ligand 2 production

Homologs

No Homologs available.

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