C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocilin, trabecular meshwork inducible glucocorticoid response
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000034971 MYOC 9606 - 1:171635417-171652683 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000037502 MYOC-001 171635417-171652683 protein_coding
  ENST00000614688 MYOC-201 171635419-171652633 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000037502ENST00000614688
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000037502 5.644±0.00 2.179±0.00 N/A N/A 15.384±0.00 5.034±0.00 1.478±0.00 N/A 6.672±0.00 4.608±0.00 5.115±0.00 0.662±0.00 N/A 1.478±0.00
ENST00000614688 3.091±0.00 N/A 0.050±0.00 0.053±0.00 1.554±1.30 4.684±2.54 2.105±0.57 0.315±0.02 3.940±3.88 5.721±1.41 2.416±0.00 0.506±0.10 0.220±0.06 2.643±2.21

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IDA osteoblast differentiation
GO:0001953 IDA negative regulation of cell-matrix adhesion
GO:0001968 IPI fibronectin binding
GO:0005109 IPI frizzled binding
GO:0005515 IPI:IEA protein binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005741 IDA mitochondrial outer membrane
GO:0005743 IDA mitochondrial inner membrane
GO:0005758 IDA mitochondrial intermembrane space
GO:0005783 ISS endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005929 IEA cilium
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014734 ISS skeletal muscle hypertrophy
GO:0022011 ISS myelination in peripheral nervous system
GO:0030335 IDA positive regulation of cell migration
GO:0030971 IEA receptor tyrosine kinase binding
GO:0031012 IDA extracellular matrix
GO:0031175 IMP neuron projection development
GO:0031410 IDA cytoplasmic vesicle
GO:0032027 IPI myosin light chain binding
GO:0033268 ISS node of Ranvier
GO:0035024 IDA negative regulation of Rho protein signal transduction
GO:0038031 IMP non-canonical Wnt signaling pathway via JNK cascade
GO:0038133 ISS ERBB2-ERBB3 signaling pathway
GO:0043408 IDA regulation of MAPK cascade
GO:0045162 ISS clustering of voltage-gated sodium channels
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051497 IDA negative regulation of stress fiber assembly
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0051901 IDA positive regulation of mitochondrial depolarization
GO:0060348 ISS bone development
GO:0070062 IDA extracellular vesicular exosome
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021789 myoc myocilin protein_coding Danio_rerio
ENSMUSG00000026697 Myoc myocilin protein_coding Mus_musculus

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