C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocilin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026697 Myoc 10090 + 1:162639150-162649693 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028020 Myoc-201 162639150-162649693 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028020
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028020 2.836±0.88 0.772±0.22 6.587±0.94 0.034±0.01 4.952±2.48 0.358±0.10 1.923±0.41 1.160±0.23 0.011±0.00 0.372±0.19 12.286±2.15 5.696±3.04 0.070±0.07 0.965±0.68

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007X5 CIL_0007X5_0002 VISTA 1:162530457-163133967

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IDA osteoblast differentiation
GO:0001953 ISS negative regulation of cell-matrix adhesion
GO:0001968 IEA fibronectin binding
GO:0005109 IEA frizzled binding
GO:0005515 IPI protein binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005741 ISS mitochondrial outer membrane
GO:0005743 ISS mitochondrial inner membrane
GO:0005758 ISS mitochondrial intermembrane space
GO:0005783 IDA endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005929 IEA cilium
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014734 IDA skeletal muscle hypertrophy
GO:0022011 IMP myelination in peripheral nervous system
GO:0030335 ISS positive regulation of cell migration
GO:0030971 IPI receptor tyrosine kinase binding
GO:0031012 ISS extracellular matrix
GO:0031175 ISS neuron projection development
GO:0031410 ISS cytoplasmic vesicle
GO:0032027 IEA myosin light chain binding
GO:0033268 IDA node of Ranvier
GO:0035024 IEA negative regulation of Rho protein signal transduction
GO:0038031 ISS non-canonical Wnt signaling pathway via JNK cascade
GO:0038133 IDA ERBB2-ERBB3 signaling pathway
GO:0043408 ISS regulation of MAPK cascade
GO:0045162 IMP clustering of voltage-gated sodium channels
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0051497 ISS negative regulation of stress fiber assembly
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0051901 ISS positive regulation of mitochondrial depolarization
GO:0060348 IDA bone development
GO:0070062 IEA extracellular vesicular exosome
GO:1900026 ISS positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021789 myoc myocilin protein_coding Danio_rerio
ENSG00000034971 MYOC myocilin, trabecular meshwork inducible glucocorticoid response protein_coding Homo_sapiens

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