C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cytochrome P450, family 46, subfamily A, polypeptide 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000036530 CYP46A1 9606 + 14:99684304-99727301 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261835 CYP46A1-001 99684314-99727301 protein_coding
  ENST00000380228 CYP46A1-003 99684704-99726862 protein_coding
  ENST00000554176 CYP46A1-004 99705997-99727300 protein_coding
  ENST00000554611 CYP46A1-002 99684304-99713437 nonsense_mediated_decay
  ENST00000554917 CYP46A1-005 99715810-99726269 nonsense_mediated_decay
  ENST00000556313 CYP46A1-006 99715858-99723132 protein_coding
  ENST00000556822 CYP46A1-007 99717683-99722007 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261835ENST00000380228ENST00000554176ENST00000554611ENST00000554917
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261835 0.142±0.00 0.782±0.00 N/A 11.496±5.65 1.576±0.00 0.152±0.00 0.832±0.00 0.232±0.00 0.145±0.00 N/A 0.262±0.00 1.126±0.00 0.183±0.00 0.852±0.00
ENST00000380228 0.212±0.00 N/A N/A 7.808±0.00 0.892±0.00 0.307±0.00 0.134±0.00 N/A N/A N/A N/A 0.987±0.00 0.083±0.00 N/A
ENST00000554176 N/A N/A 0.244±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.572±0.13
ENST00000554611 N/A N/A N/A 0.433±0.14 0.219±0.00 0.010±0.00 N/A 0.033±0.00 N/A 0.048±0.00 0.004±0.00 N/A 0.013±0.01 N/A
ENST00000554917 0.349±0.00 N/A N/A 19.940±0.00 2.978±0.00 N/A N/A N/A 0.312±0.00 0.198±0.00 N/A N/A 0.157±0.00 2.168±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009CK CIL_0009CK_0001 VISTA 14:99273315-99877989
CIL_0003HF CIL_0003HF_0001 CGP 14:99645110-99727301
CIL_0003HG CIL_0003HG_0001 CGP 14:99684304-99942060

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005506 IEA iron ion binding
GO:0005783 TAS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006699 TAS bile acid biosynthetic process
GO:0006707 IDA cholesterol catabolic process
GO:0006805 IDA xenobiotic metabolic process
GO:0007399 TAS nervous system development
GO:0008206 TAS bile acid metabolic process
GO:0008395 TAS steroid hydroxylase activity
GO:0016021 IEA integral component of membrane
GO:0016125 TAS sterol metabolic process
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 IDA:IEA heme binding
GO:0033781 IDA cholesterol 24-hydroxylase activity
GO:0044281 TAS small molecule metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004262 cyp46a2 cytochrome P450, family 46, subfamily A, polypeptide 2 protein_coding Danio_rerio
ENSDARG00000012137 cyp46a1 cytochrome P450, family 46, subfamily A, polypeptide 1 protein_coding Danio_rerio
ENSDARG00000039492 cyp46a4 cytochrome P450, family 46, subfamily A, polypeptide 4 protein_coding Danio_rerio
ENSDARG00000089177 CYP46A1 (4 of 5) cytochrome P450, family 46, subfamily A, polypeptide 1 protein_coding Danio_rerio
ENSDARG00000093477 CYP46A1 (5 of 5) cytochrome P450, family 46, subfamily A, polypeptide 1 protein_coding Danio_rerio
ENSMUSG00000021259 Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 protein_coding Mus_musculus

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