C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: spen family transcriptional repressor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065526 SPEN 9606 + 1:15847864-15940460 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000375759 SPEN-001 15847864-15940460 protein_coding
  ENST00000438066 SPEN-002 15873502-15911301 protein_coding
  ENST00000442985 SPEN-004 15876576-15920906 protein_coding
  ENST00000471538 SPEN-003 15873502-15876711 processed_transcript
  ENST00000487496 SPEN-005 15938583-15939544 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375759
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375759 6.304±0.00 4.340±0.00 3.507±0.00 4.168±1.34 5.227±0.00 4.430±0.09 2.483±0.92 3.167±1.92 2.631±0.87 7.254±0.00 10.730±0.00 5.820±2.80 3.059±0.20 8.019±1.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QM CIL_0007QM_0001 VISTA 1:15548708-16149793

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000166 IEA nucleotide binding
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001191 IDA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003676 IEA nucleic acid binding
GO:0003697 IEA single-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0007219 IEA Notch signaling pathway
GO:0016032 IEA viral process
GO:0017053 IDA transcriptional repressor complex
GO:0044822 IDA poly(A) RNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0050769 IMP positive regulation of neurogenesis
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074245 spen spen homolog, transcriptional regulator (Drosophila) protein_coding Danio_rerio
ENSDARG00000074332 SPEN (2 of 2) spen family transcriptional repressor protein_coding Danio_rerio
ENSMUSG00000040761 Spen SPEN homolog, transcriptional regulator (Drosophila) protein_coding Mus_musculus

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