C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SPEN homolog, transcriptional regulator (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040761 Spen 10090 - 4:141467890-141538597 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000078886 Spen-002 141467890-141538449 protein_coding
  ENSMUST00000105786 Spen-001 141467890-141538597 protein_coding
  ENSMUST00000144500 Spen-006 141495529-141516909 processed_transcript
  ENSMUST00000147227 Spen-005 141468464-141471493 processed_transcript
  ENSMUST00000152081 Spen-004 141521803-141538253 processed_transcript
  ENSMUST00000152411 Spen-003 141484593-141488312 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000078886ENSMUST00000105786
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000078886 2.289±0.91 6.682±0.79 1.233±0.15 6.104±2.73 2.993±1.54 1.929±0.42 1.415±0.67 3.210±0.42 1.117±0.42 3.886±0.54 2.183±0.56 3.254±2.48 8.616±6.52 4.940±0.20
ENSMUST00000105786 0.863±0.00 1.449±0.30 1.210±0.00 N/A 1.627±0.08 4.334±0.97 0.782±0.00 2.244±1.16 0.611±0.13 1.160±0.04 0.705±0.00 2.475±0.67 1.733±0.91 2.299±0.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QM CIL_0007QM_0002 VISTA 4:141236761-141837859

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000166 IEA nucleotide binding
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001191 IEA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003697 IDA single-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0017053 IEA transcriptional repressor complex
GO:0044822 IEA poly(A) RNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0050769 IEA positive regulation of neurogenesis
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074245 spen spen homolog, transcriptional regulator (Drosophila) protein_coding Danio_rerio
ENSDARG00000074332 SPEN (2 of 2) spen family transcriptional repressor protein_coding Danio_rerio
ENSG00000065526 SPEN spen family transcriptional repressor protein_coding Homo_sapiens

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