C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate kinase, muscle
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067225 PKM 9606 - 15:72199029-72231822 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000319622 PKM-201 72199029-72231386 protein_coding
  ENST00000335181 PKM-004 72199032-72231206 protein_coding
  ENST00000389093 PKM-202 72199029-72231386 protein_coding
  ENST00000449901 PKM-203 72199029-72231386 protein_coding
  ENST00000561609 PKM-008 72200508-72228676 protein_coding
  ENST00000562784 PKM-024 72209506-72217451 retained_intron
  ENST00000562997 PKM-017 72209751-72222531 protein_coding
  ENST00000563275 PKM-022 72206675-72208962 retained_intron
  ENST00000563986 PKM-014 72201867-72206798 retained_intron
  ENST00000564178 PKM-016 72209733-72219425 protein_coding
  ENST00000564276 PKM-026 72210060-72231190 retained_intron
  ENST00000564440 PKM-009 72199029-72204559 retained_intron
  ENST00000564993 PKM-013 72206259-72207167 retained_intron
  ENST00000565143 PKM-010 72199036-72202053 retained_intron
  ENST00000565154 PKM-006 72199590-72231113 protein_coding
  ENST00000565184 PKM-012 72199032-72231171 protein_coding
  ENST00000566809 PKM-019 72217409-72231624 protein_coding
  ENST00000567087 PKM-020 72209783-72231680 protein_coding
  ENST00000567118 PKM-005 72199105-72231190 nonsense_mediated_decay
  ENST00000568459 PKM-007 72199629-72229722 protein_coding
  ENST00000568743 PKM-025 72208666-72210026 retained_intron
  ENST00000568883 PKM-204 72199032-72231822 protein_coding
  ENST00000569050 PKM-018 72218943-72231819 protein_coding
  ENST00000569857 PKM-002 72202533-72231225 nonsense_mediated_decay
  ENST00000570166 PKM-015 72202690-72206854 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335181ENST00000389093ENST00000561609ENST00000563275ENST00000565184ENST00000567118ENST00000568743ENST00000569857
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335181 94.945±0.00 133.765±0.00 28.495±0.00 79.093±14.10 74.019±56.72 53.331±31.16 44.322±15.38 200.219±193.78 19.043±10.60 83.042±58.21 79.349±0.00 158.702±123.89 184.251±19.93 122.231±46.87
ENST00000389093 41.577±0.00 70.132±0.00 N/A 111.944±0.00 N/A 54.919±0.00 72.777±0.00 120.518±0.00 4.500±0.00 66.423±0.00 40.702±0.00 29.668±0.00 N/A N/A
ENST00000561609 N/A N/A N/A N/A N/A N/A 17.710±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000563275 N/A N/A N/A 166.881±0.00 20.947±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000565184 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 34.511±0.00
ENST00000567118 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.248±0.00
ENST00000568743 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 324.489±0.00 179.658±0.00 134.817±0.00
ENST00000569857 N/A N/A 61.074±0.00 N/A 24.211±0.00 31.704±0.00 41.351±0.00 4.014±0.00 54.385±0.00 37.245±0.00 N/A 52.104±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004GV CIL_0004GV_0002 CGP 15:72199029-72272999

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0003824 IEA catalytic activity
GO:0004743 IEA:TAS pyruvate kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 NAS cytosol
GO:0005886 IDA plasma membrane
GO:0005929 IEA cilium
GO:0005975 TAS carbohydrate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006096 IEA glycolytic process
GO:0012501 IDA programmed cell death
GO:0016310 IEA phosphorylation
GO:0023026 IDA MHC class II protein complex binding
GO:0030955 IEA potassium ion binding
GO:0031012 IDA extracellular matrix
GO:0031982 IDA vesicle
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003191 pkmb pyruvate kinase, muscle, b protein_coding Danio_rerio
ENSDARG00000003933 pkma pyruvate kinase, muscle, a protein_coding Danio_rerio
ENSMUSG00000032294 Pkm pyruvate kinase, muscle protein_coding Mus_musculus

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