C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho-associated, coiled-coil containing protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067900 ROCK1 9606 - 18:20946906-21111851 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000399799 ROCK1-001 20946906-21111851 protein_coding
  ENST00000578051 ROCK1-003 20953290-20954870 protein_coding
  ENST00000582445 ROCK1-006 21045045-21049211 retained_intron
  ENST00000583556 ROCK1-005 20969958-20982783 retained_intron
  ENST00000584687 ROCK1-002 20954854-20955467 retained_intron
  ENST00000584875 ROCK1-004 20968485-20969354 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000399799
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000399799 4.100±0.00 5.877±0.00 0.812±0.00 1.045±0.43 2.334±0.57 4.760±1.72 1.878±0.74 2.763±1.97 1.784±0.20 4.291±0.55 1.141±0.00 3.146±0.96 6.082±5.39 6.740±0.46

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005O1 CIL_0005O1_0001 CGP 18:20946906-21525417

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0003383 IEA apical constriction
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 ISS cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006939 TAS smooth muscle contraction
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007165 TAS:IEA signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0007411 TAS axon guidance
GO:0016525 IMP negative regulation of angiogenesis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017048 IEA Rho GTPase binding
GO:0022614 IDA membrane to membrane docking
GO:0030027 ISS lamellipodium
GO:0030036 IEA actin cytoskeleton organization
GO:0030155 TAS regulation of cell adhesion
GO:0032060 IEA bleb assembly
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0032970 IEA regulation of actin filament-based process
GO:0035556 IEA intracellular signal transduction
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045616 IMP regulation of keratinocyte differentiation
GO:0046872 IEA metal ion binding
GO:0050900 IDA leukocyte migration
GO:0050901 IDA leukocyte tethering or rolling
GO:0051451 ISS myoblast migration
GO:0051492 TAS regulation of stress fiber assembly
GO:0051893 TAS regulation of focal adhesion assembly
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:2000114 TAS regulation of establishment of cell polarity
GO:2000145 TAS regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058993 rock1 Rho-associated, coiled-coil containing protein kinase 1 protein_coding Danio_rerio
ENSMUSG00000024290 Rock1 Rho-associated coiled-coil containing protein kinase 1 protein_coding Mus_musculus

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