C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068903 SIRT2 9606 - 19:38878555-38899862 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000249396 SIRT2-001 38878557-38899823 protein_coding
  ENST00000358931 SIRT2-201 38878555-38899862 protein_coding
  ENST00000381766 SIRT2-016 38889087-38894277 protein_coding
  ENST00000392081 SIRT2-002 38878557-38899862 protein_coding
  ENST00000407552 SIRT2-005 38883639-38899714 protein_coding
  ENST00000414941 SIRT2-008 38880821-38899823 protein_coding
  ENST00000420440 SIRT2-010 38881100-38899678 nonsense_mediated_decay
  ENST00000423526 SIRT2-012 38889860-38899581 nonsense_mediated_decay
  ENST00000437828 SIRT2-007 38889883-38899645 protein_coding
  ENST00000443898 SIRT2-009 38881432-38899711 nonsense_mediated_decay
  ENST00000447739 SIRT2-006 38889899-38899711 protein_coding
  ENST00000451193 SIRT2-011 38889697-38899602 nonsense_mediated_decay
  ENST00000462654 SIRT2-003 38878557-38894410 retained_intron
  ENST00000476771 SIRT2-013 38889231-38899518 retained_intron
  ENST00000479290 SIRT2-004 38878557-38894108 retained_intron
  ENST00000481381 SIRT2-015 38898380-38899588 processed_transcript
  ENST00000491960 SIRT2-014 38889169-38899600 retained_intron
  ENST00000496069 SIRT2-017 38879294-38880153 retained_intron
  ENST00000613542 SIRT2-202 38879108-38894873 protein_coding
  ENST00000620437 SIRT2-203 38879073-38899733 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000249396ENST00000392081ENST00000407552ENST00000491960ENST00000613542ENST00000620437
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000249396 N/A 7.974±0.00 N/A 1.703±0.00 8.481±0.00 N/A N/A 1.600±0.00 N/A 24.129±0.00 N/A 6.176±0.61 N/A
ENST00000392081 21.519±0.00 13.156±0.00 32.373±16.83 28.660±0.00 11.432±0.00 6.741±5.29 7.320±2.76 9.546±0.00 9.822±8.53 15.397±2.96 35.092±16.89 12.464±2.07 20.317±0.00
ENST00000407552 N/A N/A N/A N/A N/A N/A N/A N/A 1.346±0.00 N/A N/A N/A N/A
ENST00000491960 N/A N/A N/A N/A N/A N/A N/A N/A 2.345±0.00 N/A N/A N/A N/A
ENST00000613542 N/A N/A 53.389±0.00 1.837±0.00 N/A 16.736±0.00 N/A N/A N/A 30.032±0.00 N/A N/A N/A
ENST00000620437 N/A N/A N/A N/A N/A N/A N/A N/A 1.831±0.00 N/A 2.179±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000183 NAS chromatin silencing at rDNA
GO:0003682 IDA chromatin binding
GO:0004407 IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005677 NAS chromatin silencing complex
GO:0005694 IDA chromosome
GO:0005720 ISS nuclear heterochromatin
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005814 IDA centriole
GO:0005819 IDA spindle
GO:0005829 IDA cytosol
GO:0005874 IDA microtubule
GO:0005886 IEA plasma membrane
GO:0006342 NAS chromatin silencing
GO:0006348 NAS chromatin silencing at telomere
GO:0006351 IEA transcription, DNA-templated
GO:0006471 NAS protein ADP-ribosylation
GO:0006476 IDA:IEA protein deacetylation
GO:0006914 IEA autophagy
GO:0007067 IEA mitotic nuclear division
GO:0007096 NAS regulation of exit from mitosis
GO:0008134 IPI transcription factor binding
GO:0008270 IDA:IEA zinc ion binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0010507 IMP negative regulation of autophagy
GO:0010801 ISS negative regulation of peptidyl-threonine phosphorylation
GO:0014065 IMP phosphatidylinositol 3-kinase signaling
GO:0016458 NAS gene silencing
GO:0016575 TAS histone deacetylation
GO:0016811 IEA hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 IDA NAD-dependent histone deacetylase activity
GO:0021762 IEP substantia nigra development
GO:0022011 ISS myelination in peripheral nervous system
GO:0030496 IDA midbody
GO:0031641 ISS regulation of myelination
GO:0032436 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033010 ISS paranodal junction
GO:0033270 ISS paranode region of axon
GO:0033558 IDA protein deacetylase activity
GO:0034599 ISS cellular response to oxidative stress
GO:0034979 IDA NAD-dependent protein deacetylase activity
GO:0034983 IDA peptidyl-lysine deacetylation
GO:0035035 IPI histone acetyltransferase binding
GO:0035729 IDA cellular response to hepatocyte growth factor stimulus
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042325 NAS regulation of phosphorylation
GO:0042826 IPI histone deacetylase binding
GO:0042903 IDA tubulin deacetylase activity
GO:0043130 IDA ubiquitin binding
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 ISS perikaryon
GO:0043209 ISS myelin sheath
GO:0043219 ISS lateral loop
GO:0043220 ISS Schmidt-Lanterman incisure
GO:0043388 ISS positive regulation of DNA binding
GO:0043491 IMP protein kinase B signaling
GO:0044224 ISS juxtaparanode region of axon
GO:0044242 ISS cellular lipid catabolic process
GO:0045087 IEA innate immune response
GO:0045598 IEA regulation of fat cell differentiation
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045836 ISS positive regulation of meiosis
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046970 IDA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048012 IDA hepatocyte growth factor receptor signaling pathway
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048487 IEA beta-tubulin binding
GO:0051287 IEA NAD binding
GO:0051321 IEA meiotic cell cycle
GO:0051726 IMP regulation of cell cycle
GO:0051775 NAS response to redox state
GO:0051781 ISS positive regulation of cell division
GO:0051987 ISS positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 IMP negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 ISS cellular response to caloric restriction
GO:0070403 IEA:IDA NAD+ binding
GO:0070446 ISS negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 IMP histone H3 deacetylation
GO:0070933 IDA histone H4 deacetylation
GO:0071219 IDA cellular response to molecule of bacterial origin
GO:0071456 IDA cellular response to hypoxia
GO:0071872 ISS cellular response to epinephrine stimulus
GO:0072686 IDA mitotic spindle
GO:0072687 ISS meiotic spindle
GO:0090042 ISS tubulin deacetylation
GO:0097386 ISS glial cell projection
GO:1900119 ISS positive regulation of execution phase of apoptosis
GO:1900195 ISS positive regulation of oocyte maturation
GO:1900226 IEA negative regulation of NLRP3 inflammasome complex assembly
GO:1900425 IMP negative regulation of defense response to bacterium
GO:1901026 IEA ripoptosome assembly involved in necroptotic process
GO:2000378 ISS negative regulation of reactive oxygen species metabolic process
GO:2000777 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011488 sirt2 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000015149 Sirt2 sirtuin 2 protein_coding Mus_musculus

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