C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000015149 Sirt2 10090 + 7:28766735-28788665 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000072965 Sirt2-001 28766767-28788660 protein_coding
  ENSMUST00000122915 Sirt2-002 28766735-28788660 processed_transcript
  ENSMUST00000127953 Sirt2-006 28785383-28787626 retained_intron
  ENSMUST00000128961 Sirt2-005 28785557-28788260 retained_intron
  ENSMUST00000132789 Sirt2-007 28784626-28787767 processed_transcript
  ENSMUST00000141077 Sirt2-004 28776858-28777684 retained_intron
  ENSMUST00000153956 Sirt2-003 28777008-28783339 retained_intron
  ENSMUST00000155327 Sirt2-008 28767254-28788660 processed_transcript
  ENSMUST00000170068 Sirt2-201 28766752-28788665 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000072965ENSMUST00000122915ENSMUST00000128961ENSMUST00000155327ENSMUST00000170068
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000072965 8.175±0.30 10.034±0.00 10.863±0.02 9.891±2.28 8.212±0.81 10.138±1.68 5.904±0.00 9.877±0.00 5.848±2.38 N/A 23.907±2.84 8.833±0.38 13.712±7.65 28.232±4.01
ENSMUST00000122915 24.960±2.57 15.179±3.58 28.235±0.69 18.245±7.99 14.636±5.80 12.484±2.99 19.660±2.25 28.702±1.63 13.549±2.66 25.240±3.45 24.203±2.73 21.123±5.82 12.152±5.00 31.215±5.63
ENSMUST00000128961 N/A N/A N/A 47.276±0.00 N/A N/A N/A N/A N/A N/A N/A 39.829±0.00 17.574±1.93 52.665±0.00
ENSMUST00000155327 N/A N/A N/A N/A 5.713±0.00 N/A N/A 6.234±0.23 N/A 10.177±0.00 N/A 9.279±2.39 8.382±0.00 20.446±4.19
ENSMUST00000170068 N/A N/A N/A N/A 13.387±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006UY CIL_0006UY_0002 CGP 7:28766735-28798963

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0003682 ISS chromatin binding
GO:0004407 ISS histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005694 ISS chromosome
GO:0005720 ISS nuclear heterochromatin
GO:0005737 ISS cytoplasm
GO:0005813 ISS centrosome
GO:0005814 ISS centriole
GO:0005819 ISS spindle
GO:0005829 ISS cytosol
GO:0005874 ISS microtubule
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IMP protein deacetylation
GO:0006914 IEA autophagy
GO:0007067 IEA mitotic nuclear division
GO:0008134 ISS transcription factor binding
GO:0008285 ISS negative regulation of cell proliferation
GO:0010507 ISS negative regulation of autophagy
GO:0010801 IMP negative regulation of peptidyl-threonine phosphorylation
GO:0014065 ISS phosphatidylinositol 3-kinase signaling
GO:0016575 IGI histone deacetylation
GO:0017136 ISS NAD-dependent histone deacetylase activity
GO:0021762 IEA substantia nigra development
GO:0022011 IMP myelination in peripheral nervous system
GO:0030496 ISS midbody
GO:0031641 IMP regulation of myelination
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033010 IDA paranodal junction
GO:0033270 ISS paranode region of axon
GO:0033558 IMP protein deacetylase activity
GO:0034599 IDA cellular response to oxidative stress
GO:0034979 ISS NAD-dependent protein deacetylase activity
GO:0034983 ISS peptidyl-lysine deacetylation
GO:0035035 ISS histone acetyltransferase binding
GO:0035729 ISS cellular response to hepatocyte growth factor stimulus
GO:0042177 ISS negative regulation of protein catabolic process
GO:0042826 ISS histone deacetylase binding
GO:0042903 ISS tubulin deacetylase activity
GO:0043130 ISS ubiquitin binding
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 IDA perikaryon
GO:0043209 IDA myelin sheath
GO:0043219 ISS lateral loop
GO:0043220 IDA Schmidt-Lanterman incisure
GO:0043388 IDA positive regulation of DNA binding
GO:0043491 ISS protein kinase B signaling
GO:0044224 ISS juxtaparanode region of axon
GO:0044242 IMP cellular lipid catabolic process
GO:0045598 IMP regulation of fat cell differentiation
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045836 IMP positive regulation of meiosis
GO:0045843 ISS negative regulation of striated muscle tissue development
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046970 ISS NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048012 ISS hepatocyte growth factor receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048487 IDA beta-tubulin binding
GO:0051321 IEA meiotic cell cycle
GO:0051726 ISS regulation of cell cycle
GO:0051781 IMP positive regulation of cell division
GO:0051987 IMP positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 ISS negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 IDA cellular response to caloric restriction
GO:0070403 IEA NAD+ binding
GO:0070446 ISS negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 IMP histone H3 deacetylation
GO:0070933 ISS histone H4 deacetylation
GO:0071219 ISS cellular response to molecule of bacterial origin
GO:0071456 ISS cellular response to hypoxia
GO:0071872 IDA cellular response to epinephrine stimulus
GO:0072686 ISS mitotic spindle
GO:0072687 IDA meiotic spindle
GO:0090042 IGI tubulin deacetylation
GO:0097386 ISS glial cell projection
GO:1900119 IMP positive regulation of execution phase of apoptosis
GO:1900195 IMP positive regulation of oocyte maturation
GO:1900226 IMP negative regulation of NLRP3 inflammasome complex assembly
GO:1900425 IMP negative regulation of defense response to bacterium
GO:1901026 IMP ripoptosome assembly involved in necroptotic process
GO:2000378 IMP negative regulation of reactive oxygen species metabolic process
GO:2000777 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011488 sirt2 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) protein_coding Danio_rerio
ENSG00000068903 SIRT2 sirtuin 2 protein_coding Homo_sapiens

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