C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopamine receptor D4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000069696 DRD4 9606 + 11:637293-640706 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000176183 DRD4-001 637293-640706 protein_coding
  ENST00000528733 DRD4-002 639057-639793 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000176183ENST00000528733
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000176183 0.311±0.00 0.463±0.00 0.398±0.22 0.255±0.00 0.165±0.00 0.051±0.00 0.361±0.00 0.504±0.00 1.058±0.00 0.934±0.00 1.039±0.93 0.502±0.34 1.348±0.52
ENST00000528733 0.233±0.00 0.625±0.00 N/A N/A N/A N/A 0.740±0.00 1.153±0.00 N/A N/A N/A N/A 0.245±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003OQ CIL_0003OQ_0001 CGP 11:626431-640706
CIL_0003OP CIL_0003OP_0001 CGP 11:637293-706715

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001591 ISS dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001662 NAS behavioral fear response
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001975 ISS response to amphetamine
GO:0004930 IEA G-protein coupled receptor activity
GO:0004952 IDA dopamine neurotransmitter receptor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005938 IEA cell cortex
GO:0006874 IC cellular calcium ion homeostasis
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007194 IDA negative regulation of adenylate cyclase activity
GO:0007195 IDA adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 IDA dopamine receptor signaling pathway
GO:0007614 IEA short-term memory
GO:0007623 IEA circadian rhythm
GO:0008144 IDA drug binding
GO:0008306 IEA associative learning
GO:0008344 ISS adult locomotory behavior
GO:0008355 IEA olfactory learning
GO:0009648 IEA photoperiodism
GO:0012506 IEA vesicle membrane
GO:0015459 NAS potassium channel regulator activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0017124 IDA SH3 domain binding
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030818 IDA negative regulation of cAMP biosynthetic process
GO:0032417 IDA positive regulation of sodium:proton antiporter activity
GO:0033674 IDA positive regulation of kinase activity
GO:0034776 IDA response to histamine
GO:0035176 NAS social behavior
GO:0035240 IDA dopamine binding
GO:0042053 ISS regulation of dopamine metabolic process
GO:0042417 IC dopamine metabolic process
GO:0042596 ISS fear response
GO:0042752 ISS regulation of circadian rhythm
GO:0042802 IPI identical protein binding
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0043679 IEA axon terminus
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0048148 ISS behavioral response to cocaine
GO:0048149 TAS behavioral response to ethanol
GO:0048545 IEA response to steroid hormone
GO:0050482 IDA arachidonic acid secretion
GO:0050709 IDA negative regulation of protein secretion
GO:0050804 IEA regulation of synaptic transmission
GO:0050848 IEA regulation of calcium-mediated signaling
GO:0051586 IC positive regulation of dopamine uptake involved in synaptic transmission
GO:0060041 IEA retina development in camera-type eye
GO:0060080 ISS regulation of inhibitory postsynaptic membrane potential
GO:0060406 IEA positive regulation of penile erection
GO:1901386 IDA negative regulation of voltage-gated calcium channel activity
GO:2000463 IEA positive regulation of excitatory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035820 drd4b dopamine receptor D4b protein_coding Danio_rerio
ENSDARG00000038363 drd4a dopamine receptor D4a protein_coding Danio_rerio
ENSMUSG00000025496 Drd4 dopamine receptor D4 protein_coding Mus_musculus

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