C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dopamine receptor D4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025496 Drd4 10090 + 7:141292006-141294999 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026569 Drd4-201 141292006-141294999 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000026569
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000026569 0.043±0.03 3.221±2.99 0.171±0.00 0.386±0.26 0.072±0.02 0.116±0.07 0.030±0.01 0.045±0.03 0.013±0.01 0.015±0.00 7.294±4.22 2.827±0.98 4.210±2.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003OQ CIL_0003OQ_0002 CGP 7:141278331-141294999
CIL_0003OP CIL_0003OP_0002 CGP 7:141292006-141327725

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001591 IMP dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001662 IEA behavioral fear response
GO:0001963 IEA synaptic transmission, dopaminergic
GO:0001975 IMP response to amphetamine
GO:0004952 IEA dopamine neurotransmitter receptor activity
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005938 IEA cell cortex
GO:0007194 IEA negative regulation of adenylate cyclase activity
GO:0007195 IMP adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 IEA dopamine receptor signaling pathway
GO:0007614 IEA short-term memory
GO:0007623 IEA circadian rhythm
GO:0008144 IEA drug binding
GO:0008306 IEA associative learning
GO:0008344 IMP adult locomotory behavior
GO:0008355 IEA olfactory learning
GO:0009648 IEA photoperiodism
GO:0012506 IEA vesicle membrane
GO:0016020 IEA membrane
GO:0017124 IEA SH3 domain binding
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030818 IEA negative regulation of cAMP biosynthetic process
GO:0032417 IEA positive regulation of sodium:proton antiporter activity
GO:0033674 IEA positive regulation of kinase activity
GO:0034776 IEA response to histamine
GO:0035240 IEA dopamine binding
GO:0042053 IMP regulation of dopamine metabolic process
GO:0042596 IMP fear response
GO:0042752 IMP regulation of circadian rhythm
GO:0042802 IEA identical protein binding
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0043679 IEA axon terminus
GO:0046928 IEA regulation of neurotransmitter secretion
GO:0048148 IMP behavioral response to cocaine
GO:0048545 IEA response to steroid hormone
GO:0050482 IEA arachidonic acid secretion
GO:0050709 IEA negative regulation of protein secretion
GO:0050804 IEA regulation of synaptic transmission
GO:0050848 IEA regulation of calcium-mediated signaling
GO:0060041 IEA retina development in camera-type eye
GO:0060080 IMP regulation of inhibitory postsynaptic membrane potential
GO:0060406 IEA positive regulation of penile erection
GO:1901386 IEA negative regulation of voltage-gated calcium channel activity
GO:2000463 IEA positive regulation of excitatory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035820 drd4b dopamine receptor D4b protein_coding Danio_rerio
ENSDARG00000038363 drd4a dopamine receptor D4a protein_coding Danio_rerio
ENSG00000069696 DRD4 dopamine receptor D4 protein_coding Homo_sapiens

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