C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 4 receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077238 IL4R 9606 + 16:27313668-27364778 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000170630 IL4R-201 27341289-27364777 protein_coding
  ENST00000395762 IL4R-001 27313913-27364778 protein_coding
  ENST00000543915 IL4R-004 27313926-27364778 protein_coding
  ENST00000561742 IL4R-006 27313926-27340234 protein_coding
  ENST00000561946 IL4R-013 27314030-27345090 retained_intron
  ENST00000562142 IL4R-009 27313923-27342241 protein_coding
  ENST00000562968 IL4R-012 27344908-27345602 protein_coding
  ENST00000563002 IL4R-007 27313992-27345020 protein_coding
  ENST00000563787 IL4R-008 27315397-27345039 retained_intron
  ENST00000563886 IL4R-016 27355348-27362296 retained_intron
  ENST00000563926 IL4R-010 27313926-27342154 nonsense_mediated_decay
  ENST00000565179 IL4R-018 27352550-27362373 protein_coding
  ENST00000565352 IL4R-017 27352675-27364297 protein_coding
  ENST00000565696 IL4R-011 27342031-27346618 retained_intron
  ENST00000565915 IL4R-015 27354083-27362483 processed_transcript
  ENST00000566117 IL4R-005 27313668-27345020 protein_coding
  ENST00000566318 IL4R-014 27313938-27355876 nonsense_mediated_decay
  ENST00000568746 IL4R-003 27313934-27363903 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000170630ENST00000395762ENST00000543915ENST00000563886ENST00000563926ENST00000568746
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000170630 N/A N/A N/A 1.234±1.20 3.094±1.07 2.262±0.84 0.086±0.00 N/A 10.964±0.00 13.792±0.00 0.259±0.00 6.696±0.00 14.425±5.10 1.998±0.00
ENST00000395762 8.102±0.00 9.960±0.00 N/A 3.538±0.00 1.823±0.68 3.152±1.50 1.636±0.00 3.735±0.71 3.083±1.58 N/A 0.144±0.00 7.635±3.78 6.800±1.87 N/A
ENST00000543915 7.847±0.00 9.651±0.00 N/A 1.763±0.00 N/A 1.099±0.00 2.580±0.00 5.303±0.00 3.876±0.00 21.048±0.00 0.127±0.00 4.007±2.23 6.064±0.94 2.764±0.74
ENST00000563886 N/A N/A 0.985±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000563926 N/A N/A 0.992±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000568746 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.708±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005KN CIL_0005KN_0001 CGP 16:27224991-27364778
CIL_0005KO CIL_0005KO_0001 CGP 16:27313668-27452042

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002532 IEA production of molecular mediator involved in inflammatory response
GO:0004896 IEA cytokine receptor activity
GO:0004913 TAS interleukin-4 receptor activity
GO:0005057 TAS receptor signaling protein activity
GO:0005515 IPI:IEA protein binding
GO:0005615 IEA extracellular space
GO:0005887 TAS integral component of plasma membrane
GO:0006955 TAS immune response
GO:0007165 TAS signal transduction
GO:0016021 IEA integral component of membrane
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0030728 IEA ovulation
GO:0035556 TAS intracellular signal transduction
GO:0035771 TAS interleukin-4-mediated signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042832 IEA defense response to protozoan
GO:0043032 IEA positive regulation of macrophage activation
GO:0043235 IDA receptor complex
GO:0043627 IEA response to estrogen
GO:0045626 IEA negative regulation of T-helper 1 cell differentiation
GO:0045630 IEA positive regulation of T-helper 2 cell differentiation
GO:0090197 IEA positive regulation of chemokine secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000030748 Il4ra interleukin 4 receptor, alpha protein_coding Mus_musculus

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