C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: L-2-hydroxyglutarate dehydrogenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087299 L2HGDH 9606 - 14:50237563-50312548 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261699 L2HGDH-002 50237563-50312168 protein_coding
  ENST00000267436 L2HGDH-001 50242434-50312548 protein_coding
  ENST00000421284 L2HGDH-003 50245651-50312229 protein_coding
  ENST00000554191 L2HGDH-005 50294198-50312226 nonsense_mediated_decay
  ENST00000555423 L2HGDH-004 50282443-50312226 protein_coding
  ENST00000555610 L2HGDH-007 50283853-50312154 protein_coding
  ENST00000556393 L2HGDH-006 50302017-50312147 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000267436
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000267436 0.795±0.00 1.629±0.00 0.690±0.00 1.601±0.00 1.247±0.00 0.586±0.00 0.874±0.58 1.728±1.00 0.913±0.00 0.394±0.00 1.118±0.00 0.520±0.00 1.236±0.00 1.947±0.92

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005HL CIL_0005HL_0002 CGP 14:50117120-50312548
CIL_0005HM CIL_0005HM_0002 CGP 14:50237563-50335558

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005739 IDA mitochondrion
GO:0005743 TAS mitochondrial inner membrane
GO:0006103 TAS 2-oxoglutarate metabolic process
GO:0016021 IDA integral component of membrane
GO:0016491 IEA oxidoreductase activity
GO:0031305 NAS integral component of mitochondrial inner membrane
GO:0044237 TAS cellular metabolic process
GO:0044267 IDA cellular protein metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0047545 IDA 2-hydroxyglutarate dehydrogenase activity
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060500 l2hgdh L-2-hydroxyglutarate dehydrogenase protein_coding Danio_rerio
ENSMUSG00000020988 L2hgdh L-2-hydroxyglutarate dehydrogenase protein_coding Mus_musculus

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