C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000089163 SIRT4 9606 + 12:120302316-120313249 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000202967 SIRT4-001 120302321-120313249 protein_coding
  ENST00000536460 SIRT4-002 120302316-120304058 protein_coding
  ENST00000537892 SIRT4-003 120303880-120313241 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000202967ENST00000536460ENST00000537892
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000202967 0.029±0.00 0.300±0.00 0.538±0.00 0.831±0.00 1.124±0.00 1.000±0.40 0.439±0.07 1.231±0.00 N/A 1.765±0.00 0.605±0.21 0.269±0.04 1.790±0.00
ENST00000536460 N/A N/A 0.775±0.00 N/A 0.423±0.00 N/A N/A N/A 0.169±0.09 1.290±0.00 0.174±0.00 0.448±0.21 N/A
ENST00000537892 N/A 0.210±0.00 0.373±0.15 N/A 0.748±0.00 N/A 1.010±0.63 0.104±0.00 0.107±0.00 0.102±0.00 0.693±0.35 0.079±0.00 1.965±0.56

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009CQ CIL_0009CQ_0001 VISTA 12:119991644-120595694
CIL_0007ZA CIL_0007ZA_0001 VISTA 12:120240385-120840841

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003950 IDA NAD+ ADP-ribosyltransferase activity
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005759 IDA mitochondrial matrix
GO:0006342 TAS chromatin silencing
GO:0006471 ISS protein ADP-ribosylation
GO:0006541 ISS glutamine metabolic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0008270 IEA zinc ion binding
GO:0034979 IEA NAD-dependent protein deacetylase activity
GO:0034983 ISS peptidyl-lysine deacetylation
GO:0046322 ISS negative regulation of fatty acid oxidation
GO:0046676 IMP negative regulation of insulin secretion
GO:0046889 ISS positive regulation of lipid biosynthetic process
GO:0070403 IEA NAD+ binding
GO:0072350 ISS tricarboxylic acid metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010415 sirt4 sirtuin 4 protein_coding Danio_rerio
ENSMUSG00000029524 Sirt4 sirtuin 4 protein_coding Mus_musculus

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