C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029524 Sirt4 10090 - 5:115478010-115484725 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000112066 Sirt4-002 115478010-115484725 protein_coding
  ENSMUST00000112067 Sirt4-001 115478010-115484297 protein_coding
  ENSMUST00000127479 Sirt4-003 115482462-115484366 retained_intron
  ENSMUST00000131121 Sirt4-005 115480160-115482856 retained_intron
  ENSMUST00000148139 Sirt4-004 115480231-115484345 processed_transcript
  ENSMUST00000154729 Sirt4-006 115478013-115479938 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000112066ENSMUST00000112067ENSMUST00000127479ENSMUST00000131121ENSMUST00000148139ENSMUST00000154729
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000112066 2.699±0.00 2.179±0.00 6.340±0.00 2.545±0.83 1.766±0.00 N/A 3.062±0.53 3.708±1.61 1.836±0.91 1.930±0.01 1.204±0.19 3.029±0.62 0.932±0.00 3.326±1.49
ENSMUST00000112067 3.198±1.07 3.262±0.81 N/A N/A 2.192±0.52 2.576±0.59 2.071±1.02 2.599±0.87 1.694±0.73 2.019±0.14 1.175±0.32 3.312±0.54 1.462±0.10 6.726±0.98
ENSMUST00000127479 4.036±0.00 5.961±0.00 N/A 5.756±1.16 3.531±0.00 4.114±0.00 N/A N/A 2.457±0.78 N/A 3.119±0.80 6.328±0.82 1.459±0.12 N/A
ENSMUST00000131121 6.201±0.93 11.037±5.31 N/A 9.427±2.94 9.894±1.16 10.622±2.53 3.948±0.36 6.157±2.08 3.548±0.94 5.457±1.09 N/A 16.871±3.16 2.011±0.07 N/A
ENSMUST00000148139 N/A 4.370±2.00 N/A N/A N/A 4.041±1.10 N/A N/A N/A N/A N/A 4.390±0.00 2.858±0.00 N/A
ENSMUST00000154729 4.932±0.13 6.377±2.03 N/A N/A 4.667±0.00 3.298±0.05 3.192±0.00 4.598±0.94 2.821±0.47 N/A 2.211±0.58 5.372±1.05 3.394±3.04 11.935±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ZA CIL_0007ZA_0002 VISTA 5:114966986-115567561
CIL_0009CQ CIL_0009CQ_0002 VISTA 5:115188390-115791906

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003950 ISS NAD+ ADP-ribosyltransferase activity
GO:0005515 IPI protein binding
GO:0005739 ISS mitochondrion
GO:0005759 ISS mitochondrial matrix
GO:0006471 IMP protein ADP-ribosylation
GO:0006541 IMP glutamine metabolic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0008270 IEA zinc ion binding
GO:0034979 IDA NAD-dependent protein deacetylase activity
GO:0034983 IDA peptidyl-lysine deacetylation
GO:0046322 IDA negative regulation of fatty acid oxidation
GO:0046676 ISS negative regulation of insulin secretion
GO:0046889 IDA positive regulation of lipid biosynthetic process
GO:0070403 IEA NAD+ binding
GO:0072350 IMP tricarboxylic acid metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010415 sirt4 sirtuin 4 protein_coding Danio_rerio
ENSG00000089163 SIRT4 sirtuin 4 protein_coding Homo_sapiens

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