C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitochondrial E3 ubiquitin protein ligase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000090432 MUL1 9606 - 1:20499448-20508161 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264198 MUL1-001 20499448-20508161 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264198
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264198 12.151±0.00 12.773±0.00 3.685±0.00 6.045±4.07 6.665±5.72 6.525±3.09 9.242±6.82 15.474±12.26 6.174±2.47 5.122±1.80 7.553±3.79 12.910±9.06 17.719±5.57 10.133±5.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WA CIL_0002WA_0002 CGP 1:20499448-20555010

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000266 IMP mitochondrial fission
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0004871 IMP signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005777 IDA peroxisome
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007005 IEA mitochondrion organization
GO:0007257 IDA activation of JUN kinase activity
GO:0008270 IEA zinc ion binding
GO:0010637 IDA negative regulation of mitochondrial fusion
GO:0016020 IDA membrane
GO:0016567 IEA protein ubiquitination
GO:0016925 IEA protein sumoylation
GO:0019789 IDA SUMO ligase activity
GO:0030308 IDA negative regulation of cell growth
GO:0031307 IDA integral component of mitochondrial outer membrane
GO:0031625 IPI ubiquitin protein ligase binding
GO:0033235 IDA positive regulation of protein sumoylation
GO:0042802 IPI identical protein binding
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824 IMP negative regulation of innate immune response
GO:0050689 IMP negative regulation of defense response to virus by host
GO:0050821 IMP protein stabilization
GO:0051646 IMP mitochondrion localization
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0060339 IMP negative regulation of type I interferon-mediated signaling pathway
GO:0071360 IDA cellular response to exogenous dsRNA
GO:0071650 IMP negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 IDA positive regulation of mitochondrial fission
GO:1901028 IDA regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052527 mul1b mitochondrial E3 ubiquitin ligase 1b protein_coding Danio_rerio
ENSMUSG00000041241 Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 protein_coding Mus_musculus

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