C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitochondrial ubiquitin ligase activator of NFKB 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000041241 Mul1 10090 + 4:138434671-138442265 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000044058 Mul1-001 138434671-138442265 protein_coding
  ENSMUST00000105813 Mul1-002 138434677-138442262 protein_coding
  ENSMUST00000105815 Mul1-003 138434723-138439011 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000044058ENSMUST00000105813ENSMUST00000105815
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000044058 3.340±0.06 4.332±0.00 1.186±0.00 1.120±0.22 2.012±0.40 8.703±3.08 4.263±1.58 4.030±0.44 1.977±1.55 2.759±0.90 N/A 3.524±1.36 1.890±1.32 5.682±2.75
ENSMUST00000105813 5.694±1.99 7.591±0.83 4.323±0.79 3.674±0.41 5.584±1.14 7.733±0.61 4.628±0.54 7.616±1.61 6.143±3.71 3.787±0.46 4.976±1.97 5.306±2.33 3.218±0.95 11.550±5.50
ENSMUST00000105815 N/A N/A 9.062±0.00 43.396±0.00 N/A N/A N/A N/A 8.581±0.93 N/A N/A 31.289±0.00 28.528±11.77 62.984±19.69

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000266 ISS mitochondrial fission
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0004871 ISS signal transducer activity
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005777 ISS peroxisome
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257 ISS activation of JUN kinase activity
GO:0008270 IEA zinc ion binding
GO:0010637 IEA negative regulation of mitochondrial fusion
GO:0016020 IEA membrane
GO:0016567 ISS protein ubiquitination
GO:0016925 IEA protein sumoylation
GO:0019789 IEA SUMO ligase activity
GO:0030308 ISS negative regulation of cell growth
GO:0031307 ISS integral component of mitochondrial outer membrane
GO:0031625 IEA ubiquitin protein ligase binding
GO:0033235 IEA positive regulation of protein sumoylation
GO:0042802 ISS identical protein binding
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824 ISS negative regulation of innate immune response
GO:0050689 ISS negative regulation of defense response to virus by host
GO:0050821 IEA protein stabilization
GO:0051646 ISS mitochondrion localization
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0060339 ISS negative regulation of type I interferon-mediated signaling pathway
GO:0071360 ISS cellular response to exogenous dsRNA
GO:0071650 ISS negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141 IEA positive regulation of mitochondrial fission
GO:1901028 ISS regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052527 mul1b mitochondrial E3 ubiquitin ligase 1b protein_coding Danio_rerio
ENSG00000090432 MUL1 mitochondrial E3 ubiquitin protein ligase 1 protein_coding Homo_sapiens

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