C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000092969 TGFB2 9606 + 1:218346235-218444619 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366929 TGFB2-002 218346235-218444619 protein_coding
  ENST00000366930 TGFB2-001 218346235-218444619 protein_coding
  ENST00000479322 TGFB2-004 218434126-218442141 processed_transcript
  ENST00000488793 TGFB2-003 218347038-218434312 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366929ENST00000366930ENST00000479322
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366929 0.377±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.624±0.00 N/A 0.301±0.00 N/A 1.258±0.00
ENST00000366930 N/A 1.421±0.00 0.153±0.00 2.077±0.34 1.622±0.14 0.765±0.29 0.255±0.02 0.647±0.50 0.620±0.58 1.545±0.56 0.500±0.09 1.354±0.49 4.495±0.85 0.632±0.08
ENST00000479322 0.245±0.00 0.654±0.00 0.492±0.00 N/A N/A 0.586±0.18 N/A 0.509±0.00 N/A N/A N/A 1.453±0.00 1.511±0.00 0.417±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007JY CIL_0007JY_0001 UCNEbase 1:215651193-218349979
CIL_00086U CIL_00086U_0001 VISTA 1:217748935-218350744

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IDA cell morphogenesis
GO:0001501 IEA skeletal system development
GO:0001502 IEA cartilage condensation
GO:0001525 TAS angiogenesis
GO:0001540 IDA beta-amyloid binding
GO:0001568 IEA blood vessel development
GO:0001654 IDA eye development
GO:0001666 IMP response to hypoxia
GO:0001837 IDA epithelial to mesenchymal transition
GO:0001942 ISS hair follicle development
GO:0001974 IEA blood vessel remodeling
GO:0002576 TAS platelet degranulation
GO:0003007 IDA heart morphogenesis
GO:0003179 IEA heart valve morphogenesis
GO:0004702 IDA receptor signaling protein serine/threonine kinase activity
GO:0005102 IMP receptor binding
GO:0005114 IDA type II transforming growth factor beta receptor binding
GO:0005125 TAS cytokine activity
GO:0005160 IDA transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005615 IDA:IEA extracellular space
GO:0005768 IEA endosome
GO:0006468 IDA protein phosphorylation
GO:0007050 IDA cell cycle arrest
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007184 IDA SMAD protein import into nucleus
GO:0007267 TAS cell-cell signaling
GO:0007411 IEA axon guidance
GO:0007435 IEP salivary gland morphogenesis
GO:0007507 IDA heart development
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008219 IDA cell death
GO:0008283 TAS cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008347 IDA glial cell migration
GO:0009611 IEP response to wounding
GO:0009790 TAS embryo development
GO:0010002 IDA cardioblast differentiation
GO:0010628 IEA positive regulation of gene expression
GO:0010634 IDA positive regulation of epithelial cell migration
GO:0010693 IDA negative regulation of alkaline phosphatase activity
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010936 IDA negative regulation of macrophage cytokine production
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049 IEA cell growth
GO:0016477 IDA cell migration
GO:0022601 IEP menstrual cycle phase
GO:0023014 IDA signal transduction by phosphorylation
GO:0030097 ISS hemopoiesis
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030199 IDA collagen fibril organization
GO:0030307 IDA positive regulation of cell growth
GO:0030308 IDA negative regulation of cell growth
GO:0030424 ISS axon
GO:0030593 ISS neutrophil chemotaxis
GO:0031012 IDA extracellular matrix
GO:0031069 ISS hair follicle morphogenesis
GO:0031093 TAS platelet alpha granule lumen
GO:0032147 IDA activation of protein kinase activity
GO:0032570 IDA response to progesterone
GO:0032874 IDA positive regulation of stress-activated MAPK cascade
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0033630 IDA positive regulation of cell adhesion mediated by integrin
GO:0040007 IEA growth
GO:0042060 ISS wound healing
GO:0042416 ISS dopamine biosynthetic process
GO:0042476 NAS odontogenesis
GO:0042493 IDA response to drug
GO:0042637 IDA catagen
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043025 ISS neuronal cell body
GO:0043525 IDA positive regulation of neuron apoptotic process
GO:0045216 IDA cell-cell junction organization
GO:0045726 IDA positive regulation of integrin biosynthetic process
GO:0045778 IEP positive regulation of ossification
GO:0045787 ISS positive regulation of cell cycle
GO:0045823 IDA positive regulation of heart contraction
GO:0046982 TAS protein heterodimerization activity
GO:0048103 ISS somatic stem cell division
GO:0048566 IEP embryonic digestive tract development
GO:0048663 IEA neuron fate commitment
GO:0048666 ISS neuron development
GO:0048699 TAS generation of neurons
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050714 IDA positive regulation of protein secretion
GO:0050777 TAS negative regulation of immune response
GO:0050778 ISS positive regulation of immune response
GO:0051781 IEA positive regulation of cell division
GO:0051795 IDA positive regulation of catagen
GO:0051891 IDA positive regulation of cardioblast differentiation
GO:0060038 IDA cardiac muscle cell proliferation
GO:0060317 IDA cardiac epithelial to mesenchymal transition
GO:0060325 IEA face morphogenesis
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0061037 IEA negative regulation of cartilage development
GO:0070237 IEA positive regulation of activation-induced cell death of T cells
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:1903053 IEA regulation of extracellular matrix organization
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027087 tgfb2 transforming growth factor, beta 2 protein_coding Danio_rerio
ENSMUSG00000039239 Tgfb2 transforming growth factor, beta 2 protein_coding Mus_musculus

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