C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: catechol-O-methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000093010 COMT 9606 + 22:19941607-19969975 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000207636 COMT-007 19950979-19969016 nonsense_mediated_decay
  ENST00000361682 COMT-011 19941607-19969975 protein_coding
  ENST00000403184 COMT-004 19941733-19965645 protein_coding
  ENST00000403710 COMT-002 19941773-19968958 protein_coding
  ENST00000406520 COMT-001 19951503-19969016 protein_coding
  ENST00000407537 COMT-003 19941788-19968998 protein_coding
  ENST00000412786 COMT-005 19950942-19968589 protein_coding
  ENST00000428707 COMT-008 19963699-19967694 protein_coding
  ENST00000449653 COMT-012 19962570-19968998 protein_coding
  ENST00000467943 COMT-009 19941793-19962876 retained_intron
  ENST00000493893 COMT-010 19963345-19964300 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361682ENST00000406520ENST00000407537ENST00000412786ENST00000449653ENST00000467943ENST00000493893
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361682 N/A N/A 0.964±0.00 N/A N/A N/A 0.648±0.00 N/A 1.870±0.00 N/A N/A N/A N/A 7.817±0.00
ENST00000406520 N/A N/A 2.272±0.00 N/A N/A N/A 1.494±0.00 N/A 5.012±0.00 N/A 6.099±0.00 N/A N/A N/A
ENST00000407537 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.303±0.00 N/A N/A N/A
ENST00000412786 N/A N/A N/A N/A 18.232±0.00 N/A N/A 34.443±0.00 4.887±0.00 5.410±0.00 N/A 11.551±0.00 N/A N/A
ENST00000449653 48.895±0.00 106.225±0.00 2.430±0.00 35.387±19.23 67.796±0.00 36.449±29.84 7.332±5.86 62.665±3.65 78.637±0.00 20.474±15.91 45.940±40.59 90.189±44.41 196.777±53.33 38.790±17.36
ENST00000467943 N/A N/A 5.078±0.00 N/A N/A N/A 3.492±0.00 N/A N/A 7.600±0.00 N/A N/A N/A N/A
ENST00000493893 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 149.388±0.00 135.750±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BW CIL_0008BW_0001 VISTA 22:19453681-20054184
CIL_00099J CIL_00099J_0001 VISTA 22:19461833-20062532
CIL_00095F CIL_00095F_0001 VISTA 22:19497462-20100487

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006584 IEA catecholamine metabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0007268 TAS synaptic transmission
GO:0007565 IEA female pregnancy
GO:0007612 IEA learning
GO:0007614 IEA short-term memory
GO:0008171 IEA O-methyltransferase activity
GO:0008210 IEA estrogen metabolic process
GO:0009712 IEA catechol-containing compound metabolic process
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016036 IEA cellular response to phosphate starvation
GO:0016206 IEA catechol O-methyltransferase activity
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032259 IEA methylation
GO:0032496 IEA response to lipopolysaccharide
GO:0032502 IEA developmental process
GO:0035814 IEA negative regulation of renal sodium excretion
GO:0042135 IEA neurotransmitter catabolic process
GO:0042136 TAS neurotransmitter biosynthetic process
GO:0042417 IEA dopamine metabolic process
GO:0042420 IEA dopamine catabolic process
GO:0042493 IEA response to drug
GO:0043197 IEA dendritic spine
GO:0044281 TAS small molecule metabolic process
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0045963 IEA negative regulation of dopamine metabolic process
GO:0048265 IEA response to pain
GO:0048609 IEA multicellular organismal reproductive process
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050668 IEA positive regulation of homocysteine metabolic process
GO:0051930 IEA regulation of sensory perception of pain
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015337 comta catechol-O-methyltransferase a protein_coding Danio_rerio
ENSDARG00000025679 comtb catechol-O-methyltransferase b protein_coding Danio_rerio
ENSMUSG00000000326 Comt catechol-O-methyltransferase protein_coding Mus_musculus

Loading