C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: catechol-O-methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000326 Comt 10090 - 16:18406886-18426852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000335 Comt-003 18407544-18426385 protein_coding
  ENSMUST00000115609 Comt-001 18407346-18426852 protein_coding
  ENSMUST00000147720 Comt-002 18410763-18413494 protein_coding
  ENSMUST00000165430 Comt-201 18406886-18413494 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000335ENSMUST00000115609ENSMUST00000165430
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000335 406.349±132.19 193.187±38.46 103.513±5.77 31.625±3.08 209.043±69.09 78.532±5.27 83.875±7.69 285.420±16.61 286.284±197.29 84.664±12.96 18.003±1.87 81.005±31.30 24.098±0.85 7.760±2.09
ENSMUST00000115609 N/A 22.944±0.68 17.670±2.53 N/A N/A 11.171±0.84 19.716±0.79 N/A 38.473±3.92 N/A N/A 17.089±1.76 N/A N/A
ENSMUST00000165430 39.737±0.00 N/A 23.368±6.19 9.085±0.00 N/A N/A 17.169±0.65 N/A 119.939±46.80 N/A 5.148±1.12 13.394±6.30 15.735±1.94 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00095F CIL_00095F_0002 VISTA 16:18254168-18857637
CIL_00099J CIL_00099J_0002 VISTA 16:18285741-18886132
CIL_0008BW CIL_0008BW_0002 VISTA 16:18293232-18893684

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0005739 IDA mitochondrion
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0007565 IEA female pregnancy
GO:0007612 IEA learning
GO:0007614 IEA short-term memory
GO:0008210 IEA estrogen metabolic process
GO:0009712 IMP catechol-containing compound metabolic process
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016036 IDA cellular response to phosphate starvation
GO:0016206 IMP catechol O-methyltransferase activity
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032259 IEA methylation
GO:0032496 IEA response to lipopolysaccharide
GO:0032502 IEA developmental process
GO:0035814 IEA negative regulation of renal sodium excretion
GO:0042135 IEA neurotransmitter catabolic process
GO:0042417 IMP dopamine metabolic process
GO:0042420 IDA dopamine catabolic process
GO:0042493 IEA response to drug
GO:0043197 IEA dendritic spine
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0045963 IEA negative regulation of dopamine metabolic process
GO:0048265 IEA response to pain
GO:0048609 IEA multicellular organismal reproductive process
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050668 IEA positive regulation of homocysteine metabolic process
GO:0051930 IEA regulation of sensory perception of pain
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015337 comta catechol-O-methyltransferase a protein_coding Danio_rerio
ENSDARG00000025679 comtb catechol-O-methyltransferase b protein_coding Danio_rerio
ENSG00000093010 COMT catechol-O-methyltransferase protein_coding Homo_sapiens

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