C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol 1,4,5-trisphosphate receptor, type 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000096433 ITPR3 9606 + 6:33620365-33696574 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374316 ITPR3-001 33620365-33696574 protein_coding
  ENST00000605930 ITPR3-201 33621379-33696569 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374316ENST00000605930
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374316 N/A N/A N/A N/A N/A N/A N/A N/A 0.248±0.00 N/A N/A N/A N/A N/A
ENST00000605930 6.155±0.00 5.383±0.00 0.232±0.00 0.510±0.30 1.889±0.29 4.504±1.41 1.034±0.41 3.362±2.91 0.983±0.00 6.463±3.19 0.777±0.00 17.398±16.85 1.894±0.08 5.899±2.42

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000255 CIL_000255_0001 CGP 6:33572547-33696574
CIL_00024Y CIL_00024Y_0001 CGP 6:33620365-33711727

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000822 ISS inositol hexakisphosphate binding
GO:0005216 IEA ion channel activity
GO:0005218 ISS intracellular ligand-gated calcium channel activity
GO:0005220 ISS inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 IEA calcium channel activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005640 ISS nuclear outer membrane
GO:0005654 IEA nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0005783 ISS endoplasmic reticulum
GO:0005789 ISS endoplasmic reticulum membrane
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005903 ISS brush border
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 ISS G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0007596 TAS blood coagulation
GO:0007613 IEA memory
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016020 IDA:IEA membrane
GO:0030168 TAS platelet activation
GO:0031095 TAS platelet dense tubular network membrane
GO:0035091 IEA phosphatidylinositol binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043025 ISS neuronal cell body
GO:0043209 ISS myelin sheath
GO:0043235 IDA receptor complex
GO:0043533 ISS inositol 1,3,4,5 tetrakisphosphate binding
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045177 ISS apical part of cell
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048016 IEA inositol phosphate-mediated signaling
GO:0050796 TAS regulation of insulin secretion
GO:0050913 IEA sensory perception of bitter taste
GO:0050916 IEA sensory perception of sweet taste
GO:0050917 IEA sensory perception of umami taste
GO:0051260 ISS protein homooligomerization
GO:0051291 ISS protein heterooligomerization
GO:0051592 IDA response to calcium ion
GO:0055085 IEA transmembrane transport
GO:0060291 IEA long-term synaptic potentiation
GO:0060402 ISS calcium ion transport into cytosol
GO:0070588 IEA calcium ion transmembrane transport
GO:0070679 IDA inositol 1,4,5 trisphosphate binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061741 itpr3 inositol 1,4,5-triphosphate receptor, type 3 protein_coding Danio_rerio
ENSMUSG00000042644 Itpr3 inositol 1,4,5-triphosphate receptor 3 protein_coding Mus_musculus

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