C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth arrest and DNA-damage-inducible, beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099860 GADD45B 9606 + 19:2476122-2478259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215631 GADD45B-001 2476127-2478259 protein_coding
  ENST00000585359 GADD45B-007 2476146-2477657 nonsense_mediated_decay
  ENST00000586759 GADD45B-008 2476122-2476638 retained_intron
  ENST00000587345 GADD45B-006 2476148-2477436 protein_coding
  ENST00000587887 GADD45B-003 2476356-2477126 protein_coding
  ENST00000592937 GADD45B-009 2476127-2478259 retained_intron
  ENST00000593043 GADD45B-004 2476356-2477126 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000215631ENST00000585359ENST00000586759ENST00000592937
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000215631 61.013±0.00 44.952±0.00 4.385±0.00 33.802±26.38 17.629±4.99 31.963±29.85 12.114±11.48 37.102±34.19 30.634±23.82 189.307±180.18 12.602±0.04 72.880±69.09 78.387±13.90 21.045±12.53
ENST00000585359 29.366±0.00 N/A 1.594±0.00 29.917±0.00 N/A 19.904±17.50 N/A N/A 5.582±0.00 7.154±0.00 7.040±0.00 6.703±0.00 34.212±0.00 17.271±0.00
ENST00000586759 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.953±0.00 N/A N/A
ENST00000592937 N/A 23.777±0.00 N/A N/A 8.064±0.00 0.674±0.00 0.150±0.00 N/A 1.611±0.00 N/A N/A 20.138±14.67 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001IA CIL_0001IA_0001 CGP 19:2427638-2478259
CIL_0005QM CIL_0005QM_0002 CGP 19:2476122-2702709

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000185 IDA activation of MAPKKK activity
GO:0000186 IEA activation of MAPKK activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006915 IEA apoptotic process
GO:0006950 IEA response to stress
GO:0007275 IEA multicellular organismal development
GO:0030154 IEA cell differentiation
GO:0043065 IDA positive regulation of apoptotic process
GO:0046330 IDA positive regulation of JNK cascade
GO:0051726 IEA regulation of cell cycle
GO:1900745 IDA positive regulation of p38MAPK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013576 gadd45bb growth arrest and DNA-damage-inducible, beta b protein_coding Danio_rerio
ENSDARG00000027744 gadd45ba growth arrest and DNA-damage-inducible, beta a protein_coding Danio_rerio
ENSMUSG00000015312 Gadd45b growth arrest and DNA-damage-inducible 45 beta protein_coding Mus_musculus

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