C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MAP kinase interacting serine/threonine kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099875 MKNK2 9606 - 19:2037465-2051244 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250896 MKNK2-201 2037482-2051244 protein_coding
  ENST00000309340 MKNK2-001 2037465-2051224 protein_coding
  ENST00000585667 MKNK2-008 2040132-2043532 retained_intron
  ENST00000586620 MKNK2-007 2040309-2042078 retained_intron
  ENST00000586828 MKNK2-003 2039412-2050853 nonsense_mediated_decay
  ENST00000587416 MKNK2-002 2037473-2042676 retained_intron
  ENST00000588014 MKNK2-010 2038248-2042633 protein_coding
  ENST00000589441 MKNK2-011 2037465-2041842 nonsense_mediated_decay
  ENST00000589509 MKNK2-006 2046461-2051244 protein_coding
  ENST00000589534 MKNK2-012 2046522-2051232 protein_coding
  ENST00000591142 MKNK2-005 2037465-2042140 protein_coding
  ENST00000591588 MKNK2-009 2039955-2042082 protein_coding
  ENST00000591601 MKNK2-004 2037465-2050887 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000250896ENST00000309340ENST00000585667ENST00000586828ENST00000587416ENST00000591601
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000250896 136.586±0.00 45.702±0.00 N/A 6.149±0.00 57.910±0.00 39.188±0.00 53.033±0.00 24.681±0.00 10.065±8.11 60.388±0.00 238.447±219.44 17.396±0.00 11.774±0.00 22.558±13.06
ENST00000309340 N/A N/A N/A 1.705±0.80 17.293±12.77 36.409±29.85 1.862±0.00 9.372±7.58 3.830±0.00 6.120±0.00 23.313±0.00 14.344±13.05 8.625±0.85 24.766±0.00
ENST00000585667 N/A N/A N/A N/A N/A 63.365±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000586828 N/A N/A 1.339±0.00 4.114±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.978±0.00
ENST00000587416 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.457±0.00 N/A N/A
ENST00000591601 N/A N/A 1.221±0.00 0.589±0.00 2.473±0.00 1.455±0.00 N/A N/A N/A 10.112±8.58 242.477±0.00 22.390±16.86 24.060±11.08 8.035±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018B CIL_00018B_0001 CGP 19:1985438-2051244
CIL_00018A CIL_00018A_0001 CGP 19:2037465-2096673

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IEA cytoplasm
GO:0006417 IEA regulation of translation
GO:0006468 IDA:IEA protein phosphorylation
GO:0007166 TAS cell surface receptor signaling pathway
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030097 IDA hemopoiesis
GO:0035556 IDA intracellular signal transduction
GO:0046872 IEA metal ion binding
GO:0071243 IDA cellular response to arsenic-containing substance
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011373 mknk2a MAP kinase-interacting serine/threonine kinase 2a protein_coding Danio_rerio
ENSDARG00000015164 mknk2b MAP kinase-interacting serine/threonine kinase 2b protein_coding Danio_rerio
ENSMUSG00000020190 Mknk2 MAP kinase-interacting serine/threonine kinase 2 protein_coding Mus_musculus

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