C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: translocator protein (18kDa)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100300 TSPO 9606 + 22:43151514-43163242 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329563 TSPO-004 43151931-43163210 protein_coding
  ENST00000337554 TSPO-001 43151514-43163242 protein_coding
  ENST00000396265 TSPO-201 43151935-43163241 protein_coding
  ENST00000428336 TSPO-005 43151899-43161190 protein_coding
  ENST00000472378 TSPO-003 43151573-43159672 retained_intron
  ENST00000583777 TSPO-002 43151547-43163241 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337554ENST00000428336ENST00000583777
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337554 39.099±0.00 47.041±0.00 0.532±0.00 4.236±3.08 52.199±50.66 17.174±14.30 40.745±0.00 20.541±19.28 10.919±7.72 45.783±42.67 19.916±0.00 45.730±26.32 73.603±25.13 14.118±10.81
ENST00000428336 N/A N/A N/A 0.437±0.00 1.347±0.00 N/A N/A N/A N/A 1.724±0.00 N/A 1.926±0.00 N/A 0.822±0.00
ENST00000583777 9.261±0.00 N/A N/A 1.687±1.39 N/A 17.731±0.00 0.785±0.00 N/A 0.519±0.00 N/A 3.104±0.00 41.123±0.00 30.793±10.85 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008LG CIL_0008LG_0001 VISTA 22:42800321-43401810
CIL_0008W4 CIL_0008W4_0001 VISTA 22:42938962-43540911
CIL_00046C CIL_00046C_0001 CGP 22:43132206-43163242
CIL_0004LQ CIL_0004LQ_0001 CGP 22:43151514-43187133

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005497 IEA androgen binding
GO:0005515 IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 NAS mitochondrial outer membrane
GO:0006626 TAS protein targeting to mitochondrion
GO:0006694 IEA steroid biosynthetic process
GO:0006783 TAS heme biosynthetic process
GO:0006811 IEA ion transport
GO:0006820 TAS anion transport
GO:0006821 IEA chloride transport
GO:0006869 IEA lipid transport
GO:0006915 TAS apoptotic process
GO:0007268 TAS synaptic transmission
GO:0007568 IEA aging
GO:0008202 TAS steroid metabolic process
GO:0008283 TAS cell proliferation
GO:0008347 IEA glial cell migration
GO:0008503 TAS benzodiazepine receptor activity
GO:0010042 IEA response to manganese ion
GO:0010266 IEA response to vitamin B1
GO:0010940 IEA positive regulation of necrotic cell death
GO:0014012 IEA peripheral nervous system axon regeneration
GO:0015485 TAS cholesterol binding
GO:0016021 IEA integral component of membrane
GO:0030325 IEA adrenal gland development
GO:0031965 IDA nuclear membrane
GO:0032374 TAS regulation of cholesterol transport
GO:0032570 IEA response to progesterone
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0033574 IEA response to testosterone
GO:0042493 IEA response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045019 IEA negative regulation of nitric oxide biosynthetic process
GO:0048265 IEA response to pain
GO:0048266 IEA behavioral response to pain
GO:0048678 IEA response to axon injury
GO:0050810 IEA regulation of steroid biosynthetic process
GO:0051901 IEA positive regulation of mitochondrial depolarization
GO:0051928 IEA positive regulation of calcium ion transport
GO:0060242 IEA contact inhibition
GO:0060252 IEA positive regulation of glial cell proliferation
GO:0060253 IEA negative regulation of glial cell proliferation
GO:0070062 IDA extracellular vesicular exosome
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071294 IEA cellular response to zinc ion
GO:0071476 IEA cellular hypotonic response
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026655 tspo translocator protein protein_coding Danio_rerio
ENSMUSG00000041736 Tspo translocator protein protein_coding Mus_musculus

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