C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100453 GZMB 9606 - 14:24630954-24634267 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216341 GZMB-001 24630954-24634267 protein_coding
  ENST00000382540 GZMB-201 24630971-24634267 protein_coding
  ENST00000382542 GZMB-202 24631014-24634160 protein_coding
  ENST00000415355 GZMB-003 24630954-24634209 protein_coding
  ENST00000526004 GZMB-005 24631539-24634196 protein_coding
  ENST00000530830 GZMB-006 24631164-24634174 nonsense_mediated_decay
  ENST00000532263 GZMB-004 24631014-24634160 nonsense_mediated_decay
  ENST00000554242 GZMB-007 24631014-24634160 nonsense_mediated_decay
  ENST00000616551 GZMB-203 24630971-24634160 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216341ENST00000382540ENST00000382542ENST00000415355ENST00000526004ENST00000530830ENST00000532263ENST00000554242ENST00000616551
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216341 1.619±0.00 1.693±0.00 N/A N/A 0.267±0.07 N/A 0.412±0.00 0.510±0.00 N/A 1.673±0.00 N/A 0.755±0.00 3.706±3.09 N/A
ENST00000382540 N/A N/A N/A N/A 0.212±0.00 N/A N/A N/A 0.132±0.00 N/A N/A N/A N/A N/A
ENST00000382542 N/A N/A N/A N/A N/A N/A N/A 0.185±0.00 0.277±0.00 N/A N/A N/A N/A N/A
ENST00000415355 N/A N/A N/A N/A 0.686±0.00 0.139±0.00 N/A N/A N/A 5.308±0.00 N/A 0.531±0.33 N/A 0.702±0.00
ENST00000526004 N/A N/A N/A N/A N/A N/A N/A N/A 0.124±0.00 1.078±0.00 N/A 0.132±0.00 N/A N/A
ENST00000530830 N/A N/A 0.146±0.00 0.029±0.00 0.468±0.00 N/A N/A N/A N/A N/A 0.186±0.10 N/A N/A 0.226±0.00
ENST00000532263 N/A N/A 0.589±0.00 N/A 1.003±0.00 N/A N/A N/A 0.200±0.00 N/A N/A 0.770±0.00 N/A N/A
ENST00000554242 N/A N/A N/A N/A N/A 0.423±0.00 N/A N/A N/A 8.913±0.00 N/A N/A 1.030±0.00 N/A
ENST00000616551 N/A 0.993±0.00 N/A 0.253±0.00 0.993±0.00 0.606±0.00 0.286±0.01 1.964±0.00 N/A N/A N/A 0.583±0.00 1.350±0.00 0.445±0.35

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000765 CIL_000765_0006 CGP 14:24606480-24634267

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 TAS immunological synapse
GO:0003824 IEA catalytic activity
GO:0004252 IEA:IDA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006915 TAS apoptotic process
GO:0007219 TAS Notch signaling pathway
GO:0008236 TAS serine-type peptidase activity
GO:0016020 IDA membrane
GO:0019835 IEA cytolysis
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055986 protein_coding Danio_rerio
ENSDARG00000076814 protein_coding Danio_rerio
ENSDARG00000078451 protein_coding Danio_rerio
ENSDARG00000093990 protein_coding Danio_rerio
ENSMUSG00000015437 Gzmb granzyme B protein_coding Mus_musculus
ENSMUSG00000015441 Gzmf granzyme F protein_coding Mus_musculus
ENSMUSG00000015443 Gzmn granzyme N protein_coding Mus_musculus
ENSMUSG00000022156 Gzme granzyme E protein_coding Mus_musculus
ENSMUSG00000040284 Gzmg granzyme G protein_coding Mus_musculus
ENSMUSG00000059256 Gzmd granzyme D protein_coding Mus_musculus
ENSMUSG00000079186 Gzmc granzyme C protein_coding Mus_musculus

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