C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100784 RPS6KA5 9606 - 14:90847862-91060636 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261991 RPS6KA5-201 90870828-91060594 protein_coding
  ENST00000418736 RPS6KA5-003 90893974-91060600 protein_coding
  ENST00000536315 RPS6KA5-004 90871504-91060134 protein_coding
  ENST00000554206 RPS6KA5-002 90900675-91060636 nonsense_mediated_decay
  ENST00000556178 RPS6KA5-005 90872074-90978524 nonsense_mediated_decay
  ENST00000556304 RPS6KA5-007 90906192-90911469 processed_transcript
  ENST00000556594 RPS6KA5-006 90978395-91060585 nonsense_mediated_decay
  ENST00000614987 RPS6KA5-001 90847862-91060608 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaENST00000261991ENST00000418736ENST00000536315ENST00000614987
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta
ENST00000261991 N/A N/A N/A 3.842±0.00 N/A 1.795±0.00 N/A N/A 1.367±0.00 N/A 1.457±0.00 1.906±0.20
ENST00000418736 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.816±0.00 N/A
ENST00000536315 N/A N/A N/A 5.293±0.00 2.987±0.00 4.279±0.00 1.602±0.00 8.016±0.00 2.595±0.00 1.923±0.00 2.845±0.00 N/A
ENST00000614987 0.230±0.00 0.434±0.00 0.225±0.00 0.869±0.14 N/A N/A N/A 0.080±0.00 0.559±0.00 N/A 0.461±0.00 0.806±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005CD CIL_0005CD_0001 CGP 14:90524564-91060636
CIL_0005CC CIL_0005CC_0001 CGP 14:90847862-91225632

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001818 TAS negative regulation of cytokine production
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IMP nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005840 IEA ribosome
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016572 TAS histone phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0032793 TAS positive regulation of CREB transcription factor activity
GO:0033129 IMP positive regulation of histone phosphorylation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035066 IMP positive regulation of histone acetylation
GO:0035556 IEA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043987 IMP histone H3-S10 phosphorylation
GO:0043988 IMP histone H3-S28 phosphorylation
GO:0043990 IDA histone H2A-S1 phosphorylation
GO:0045087 TAS innate immune response
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0070498 IMP interleukin-1-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060551 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 protein_coding Danio_rerio
ENSMUSG00000021180 Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 protein_coding Mus_musculus

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