C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tribbles pseudokinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101255 TRIB3 9606 + 20:362835-397559 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000217233 TRIB3-001 380617-397559 protein_coding
  ENST00000422053 TRIB3-002 381297-396748 protein_coding
  ENST00000449710 TRIB3-003 381246-396428 protein_coding
  ENST00000615226 TRIB3-004 362835-391386 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000217233ENST00000422053ENST00000449710
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000217233 4.338±0.00 1.994±0.00 0.630±0.28 0.808±0.21 0.475±0.37 0.364±0.00 1.056±0.64 4.616±4.58 2.043±0.00 0.780±0.00 5.075±3.50 2.628±0.97 0.267±0.05
ENST00000422053 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.208±0.00 3.756±0.00 0.835±0.00
ENST00000449710 N/A N/A N/A 1.311±0.00 N/A 0.098±0.00 N/A N/A N/A N/A 0.959±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00096R CIL_00096R_0001 VISTA 20:23407-624368

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003714 ISS transcription corepressor activity
GO:0004672 IEA protein kinase activity
GO:0004860 IEA protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005730 IDA nucleolus
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006469 IDA negative regulation of protein kinase activity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010827 ISS regulation of glucose transport
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019899 IEA enzyme binding
GO:0019901 ISS protein kinase binding
GO:0031625 ISS ubiquitin protein ligase binding
GO:0031965 IDA nuclear membrane
GO:0032092 ISS positive regulation of protein binding
GO:0032869 ISS cellular response to insulin stimulus
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043405 IDA regulation of MAP kinase activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045717 ISS negative regulation of fatty acid biosynthetic process
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0051443 ISS positive regulation of ubiquitin-protein transferase activity
GO:0055106 ISS ubiquitin-protein transferase regulator activity
GO:0070059 IDA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016200 trib3 tribbles homolog 3 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000032715 Trib3 tribbles homolog 3 (Drosophila) protein_coding Mus_musculus

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