C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myosin light chain kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101306 MYLK2 9606 + 20:31819308-31834689 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000375985 MYLK2-001 31819373-31834689 protein_coding
  ENST00000375994 MYLK2-002 31819308-31834689 protein_coding
  ENST00000468730 MYLK2-003 31826777-31834689 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375985ENST00000375994ENST00000468730
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375985 N/A N/A 5.183±5.04 N/A 0.018±0.00 N/A 0.036±0.00 0.141±0.00 120.986±84.98 0.111±0.08 N/A 0.262±0.08
ENST00000375994 N/A N/A N/A N/A N/A N/A N/A N/A 21.322±0.00 N/A N/A 0.108±0.00
ENST00000468730 0.061±0.00 0.184±0.04 8.294±0.00 0.090±0.00 0.010±0.00 0.196±0.00 N/A N/A N/A 0.174±0.12 0.080±0.05 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008K5 CIL_0008K5_0001 VISTA 20:31303913-31904751
CIL_00089Z CIL_00089Z_0001 VISTA 20:31373735-31977079
CIL_0008N4 CIL_0008N4_0001 VISTA 20:31410024-32010895
CIL_000319 CIL_000319_0002 CGP 20:31739271-31834689
CIL_0000JB CIL_0000JB_0001 CGP 20:31819308-31845619

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004683 ISS calmodulin-dependent protein kinase activity
GO:0004687 ISS myosin light chain kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005516 ISS calmodulin binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0006941 IDA striated muscle contraction
GO:0007274 IEA neuromuscular synaptic transmission
GO:0010628 IDA positive regulation of gene expression
GO:0014816 IEA skeletal muscle satellite cell differentiation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0030017 IC sarcomere
GO:0032971 IDA regulation of muscle filament sliding
GO:0035914 IDA skeletal muscle cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0055008 IMP cardiac muscle tissue morphogenesis
GO:0060048 IC cardiac muscle contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031698 mylk2 myosin light chain kinase 2 protein_coding Danio_rerio
ENSMUSG00000027470 Mylk2 myosin, light polypeptide kinase 2, skeletal muscle protein_coding Mus_musculus

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