C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: immunoresponsive 1 homolog (mouse)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102794 IRG1 9606 + 13:76948497-76958642 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000377462 IRG1-001 76948497-76958642 protein_coding
  ENST00000449753 IRG1-201 76952477-76958636 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainLungOvaryENST00000449753
Transcript ID Brain Lung Ovary
ENST00000449753 0.015±0.00 0.100±0.06 0.016±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000049 CIL_000049_0001 CGP 13:76880166-76958642
CIL_00004A CIL_00004A_0001 CGP 13:76948497-77002517

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002760 IDA positive regulation of antimicrobial humoral response
GO:0005739 ISS mitochondrion
GO:0006952 IDA defense response
GO:0006954 IEA inflammatory response
GO:0007566 ISS embryo implantation
GO:0008152 IDA metabolic process
GO:0019543 IEA propionate catabolic process
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032480 ISS negative regulation of type I interferon production
GO:0032496 IEA response to lipopolysaccharide
GO:0034136 ISS negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 ISS negative regulation of toll-like receptor 4 signaling pathway
GO:0035458 ISS cellular response to interferon-beta
GO:0045824 ISS negative regulation of innate immune response
GO:0047547 IEA 2-methylcitrate dehydratase activity
GO:0047613 IDA aconitate decarboxylase activity
GO:0050728 ISS negative regulation of inflammatory response
GO:0071219 ISS cellular response to molecule of bacterial origin
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071346 ISS cellular response to interferon-gamma
GO:0071347 ISS cellular response to interleukin-1
GO:0071356 ISS cellular response to tumor necrosis factor
GO:0071393 ISS cellular response to progesterone stimulus
GO:0072573 IDA tolerance induction to lipopolysaccharide
GO:2000379 ISS positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069844 irg1 immunoresponsive gene 1 protein_coding Danio_rerio
ENSMUSG00000022126 Irg1 immunoresponsive gene 1 protein_coding Mus_musculus

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