C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase D2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105287 PRKD2 9606 - 19:46674275-46717127 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000291281 PRKD2-001 46674316-46716596 protein_coding
  ENST00000433867 PRKD2-201 46674317-46717127 protein_coding
  ENST00000593363 PRKD2-010 46716165-46717112 protein_coding
  ENST00000593492 PRKD2-016 46678529-46686180 processed_transcript
  ENST00000595132 PRKD2-013 46704487-46714599 protein_coding
  ENST00000595515 PRKD2-004 46674508-46717115 protein_coding
  ENST00000597088 PRKD2-014 46710354-46714032 retained_intron
  ENST00000597390 PRKD2-018 46674314-46691985 nonsense_mediated_decay
  ENST00000597589 PRKD2-007 46674346-46697341 retained_intron
  ENST00000597641 PRKD2-012 46704337-46716244 nonsense_mediated_decay
  ENST00000598633 PRKD2-011 46704634-46717114 protein_coding
  ENST00000599019 PRKD2-008 46674339-46697325 retained_intron
  ENST00000599464 PRKD2-017 46681683-46691851 retained_intron
  ENST00000600194 PRKD2-006 46674320-46714324 protein_coding
  ENST00000601605 PRKD2-015 46697840-46714023 protein_coding
  ENST00000601806 PRKD2-002 46674275-46717082 protein_coding
  ENST00000602155 PRKD2-009 46674319-46689709 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000291281ENST00000433867ENST00000595515ENST00000597390ENST00000597589ENST00000600194ENST00000601605ENST00000601806ENST00000602155
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000291281 10.680±0.00 12.165±0.00 0.560±0.00 1.449±0.00 4.155±0.00 1.768±0.96 N/A 4.153±0.00 2.283±0.00 11.127±0.00 2.075±0.00 2.637±0.94 5.809±2.72 1.948±0.00
ENST00000433867 6.428±0.00 N/A N/A N/A N/A 3.081±0.00 1.791±0.00 3.055±0.00 0.940±0.00 24.375±0.00 N/A 8.294±2.91 9.675±0.66 4.520±0.00
ENST00000595515 N/A N/A N/A 1.012±0.00 3.246±0.00 N/A N/A N/A N/A N/A N/A 2.918±0.00 7.585±0.00 N/A
ENST00000597390 N/A N/A N/A 0.352±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000597589 N/A N/A N/A N/A N/A 1.002±0.00 N/A N/A N/A N/A N/A 1.926±1.01 4.327±0.00 3.245±0.00
ENST00000600194 N/A 7.420±0.00 N/A N/A N/A 3.758±0.00 0.669±0.00 N/A 1.017±0.00 1.154±0.00 N/A 8.248±3.20 N/A N/A
ENST00000601605 N/A N/A N/A N/A N/A 5.157±0.00 1.095±0.00 N/A N/A N/A 1.262±0.00 N/A N/A N/A
ENST00000601806 N/A N/A N/A N/A N/A 2.348±0.00 N/A N/A N/A N/A N/A 7.081±0.00 3.066±0.00 3.705±0.00
ENST00000602155 N/A N/A N/A N/A 6.857±0.00 N/A N/A N/A 1.455±0.00 N/A N/A 7.767±0.00 N/A 5.348±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 NAS protein serine/threonine kinase activity
GO:0004697 IEA protein kinase C activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0006468 IEA:NAS protein phosphorylation
GO:0007155 IEA cell adhesion
GO:0008219 IMP cell death
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0030949 IMP positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032743 ISS positive regulation of interleukin-2 production
GO:0032757 IMP positive regulation of interleukin-8 production
GO:0032793 IGI positive regulation of CREB transcription factor activity
GO:0033138 IGI positive regulation of peptidyl-serine phosphorylation
GO:0035556 IMP:IEA intracellular signal transduction
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038033 IMP positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043536 IMP positive regulation of blood vessel endothelial cell migration
GO:0045743 IMP positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045766 IMP positive regulation of angiogenesis
GO:0045785 IMP positive regulation of cell adhesion
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0050852 IDA T cell receptor signaling pathway
GO:0050862 ISS positive regulation of T cell receptor signaling pathway
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0061154 TAS endothelial tube morphogenesis
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:1901727 IGI positive regulation of histone deacetylase activity
GO:1902533 IMP positive regulation of intracellular signal transduction
GO:2000573 ISS positive regulation of DNA biosynthetic process
GO:2001028 IMP positive regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086199 PRKD2 (1 of 2) protein kinase D2 protein_coding Danio_rerio
ENSDARG00000087018 STK33 protein kinase D2 protein_coding Danio_rerio
ENSDARG00000090158 PRKD2 (2 of 2) protein kinase D2 protein_coding Danio_rerio
ENSMUSG00000041187 Prkd2 protein kinase D2 protein_coding Mus_musculus

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