C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: amyloid beta (A4) precursor-like protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105290 APLP1 9606 + 19:35867899-35879791 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000221891 APLP1-002 35868445-35879788 protein_coding
  ENST00000537454 APLP1-001 35867899-35879526 protein_coding
  ENST00000586861 APLP1-003 35869473-35879493 protein_coding
  ENST00000587274 APLP1-009 35874508-35879751 protein_coding
  ENST00000588808 APLP1-005 35873646-35879174 protein_coding
  ENST00000589298 APLP1-007 35874504-35878544 processed_transcript
  ENST00000589743 APLP1-008 35870184-35871996 protein_coding
  ENST00000590561 APLP1-004 35868563-35879788 nonsense_mediated_decay
  ENST00000590926 APLP1-006 35878525-35879190 retained_intron
  ENST00000591165 APLP1-012 35879227-35879791 processed_transcript
  ENST00000592316 APLP1-011 35870454-35874620 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000221891ENST00000537454ENST00000586861ENST00000587274ENST00000588808ENST00000589298ENST00000590561ENST00000591165ENST00000592316
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000221891 0.330±0.00 N/A 143.545±0.00 0.419±0.00 0.975±0.00 3.559±0.00 N/A 1.081±0.00 N/A 1.330±0.00 1.184±0.00 N/A
ENST00000537454 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.315±0.00 N/A N/A
ENST00000586861 N/A N/A 164.298±0.00 0.126±0.00 0.804±0.72 N/A N/A N/A N/A 0.816±0.48 0.736±0.09 4.999±0.57
ENST00000587274 0.342±0.00 N/A N/A N/A N/A N/A N/A 1.189±0.00 0.178±0.00 0.603±0.00 N/A 5.195±0.00
ENST00000588808 N/A N/A N/A 0.726±0.00 N/A N/A 0.074±0.00 N/A N/A N/A N/A N/A
ENST00000589298 N/A N/A N/A N/A N/A 0.443±0.00 N/A N/A N/A N/A 1.845±0.00 N/A
ENST00000590561 N/A N/A 48.791±33.09 N/A 1.485±0.00 N/A N/A N/A N/A N/A 0.526±0.16 2.380±0.00
ENST00000591165 N/A N/A 396.266±0.00 1.077±0.00 3.401±0.00 1.445±1.13 0.181±0.00 N/A 0.107±0.00 2.265±0.00 1.458±0.00 9.778±0.00
ENST00000592316 0.271±0.00 0.803±0.00 N/A N/A 0.088±0.00 N/A 0.099±0.06 0.504±0.37 0.129±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005604 TAS basement membrane
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006378 IEA mRNA polyadenylation
GO:0006417 IEA regulation of translation
GO:0006897 IEA endocytosis
GO:0006915 IEA apoptotic process
GO:0007155 IEA cell adhesion
GO:0007193 IC adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007399 TAS nervous system development
GO:0008201 IEA heparin binding
GO:0009887 TAS organ morphogenesis
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030198 IEA extracellular matrix organization
GO:0030818 IDA negative regulation of cAMP biosynthetic process
GO:0030900 IEA forebrain development
GO:0031694 IPI alpha-2A adrenergic receptor binding
GO:0031695 IPI alpha-2B adrenergic receptor binding
GO:0031696 IPI alpha-2C adrenergic receptor binding
GO:0042802 IPI identical protein binding
GO:0046914 IEA transition metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0071874 IDA cellular response to norepinephrine stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004148 aplp1 amyloid beta (A4) precursor-like protein 1 protein_coding Danio_rerio
ENSMUSG00000006651 Aplp1 amyloid beta (A4) precursor-like protein 1 protein_coding Mus_musculus

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