C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase recruitment domain family, member 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105483 CARD8 9606 - 19:48180770-48255946 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357778 CARD8-201 48230100-48232114 protein_coding
  ENST00000377461 CARD8-015 48209644-48232114 retained_intron
  ENST00000391898 CARD8-202 48208104-48241063 protein_coding
  ENST00000447740 CARD8-203 48208104-48249847 protein_coding
  ENST00000517510 CARD8-016 48203632-48255898 nonsense_mediated_decay
  ENST00000517778 CARD8-012 48233846-48249614 processed_transcript
  ENST00000518450 CARD8-017 48203146-48218953 nonsense_mediated_decay
  ENST00000518596 CARD8-011 48233821-48249828 retained_intron
  ENST00000518622 CARD8-001 48208086-48249668 nonsense_mediated_decay
  ENST00000518979 CARD8-014 48209644-48249668 nonsense_mediated_decay
  ENST00000519302 CARD8-024 48211897-48249816 nonsense_mediated_decay
  ENST00000519332 CARD8-003 48238334-48255893 protein_coding
  ENST00000519646 CARD8-013 48211152-48249826 nonsense_mediated_decay
  ENST00000519940 CARD8-009 48211617-48255889 protein_coding
  ENST00000520007 CARD8-019 48238336-48255898 protein_coding
  ENST00000520015 CARD8-005 48211377-48249833 protein_coding
  ENST00000520153 CARD8-007 48210787-48249826 protein_coding
  ENST00000520753 CARD8-002 48210487-48255886 protein_coding
  ENST00000521092 CARD8-023 48234278-48249826 retained_intron
  ENST00000521415 CARD8-010 48211617-48241063 nonsense_mediated_decay
  ENST00000521437 CARD8-020 48238475-48255897 protein_coding
  ENST00000521613 CARD8-004 48211566-48255946 protein_coding
  ENST00000522051 CARD8-006 48210790-48249833 retained_intron
  ENST00000522068 CARD8-018 48231729-48255911 processed_transcript
  ENST00000522431 CARD8-022 48238262-48249771 protein_coding
  ENST00000522773 CARD8-008 48210787-48249810 nonsense_mediated_decay
  ENST00000522889 CARD8-021 48234472-48255871 protein_coding
  ENST00000523579 CARD8-025 48211827-48230498 nonsense_mediated_decay
  ENST00000523668 CARD8-027 48215138-48230647 retained_intron
  ENST00000523750 CARD8-026 48233410-48234464 processed_transcript
  ENST00000600800 CARD8-029 48180770-48203952 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000377461ENST00000391898ENST00000447740ENST00000518450ENST00000518596ENST00000518622ENST00000518979ENST00000519940ENST00000520007ENST00000520153ENST00000520753ENST00000521613ENST00000522051
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000377461 N/A N/A 0.820±0.00 N/A N/A 2.785±0.00 N/A N/A N/A N/A N/A 2.093±0.44 N/A N/A
ENST00000391898 2.279±0.00 N/A N/A N/A 2.132±0.00 N/A 1.580±0.00 1.585±0.24 N/A 1.868±0.00 N/A 1.095±0.00 1.744±0.21 1.980±0.00
ENST00000447740 N/A N/A N/A N/A N/A N/A N/A N/A 0.431±0.00 N/A 0.760±0.00 N/A N/A N/A
ENST00000518450 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.455±0.00
ENST00000518596 N/A N/A 2.778±0.00 N/A N/A 7.264±0.00 N/A N/A 4.834±0.00 N/A N/A N/A N/A N/A
ENST00000518622 N/A N/A N/A N/A N/A N/A N/A 1.292±0.00 N/A N/A N/A 1.521±0.00 1.977±0.00 1.414±0.00
ENST00000518979 2.438±0.00 N/A N/A 0.538±0.00 2.609±0.00 3.014±0.00 N/A 2.043±0.00 1.019±0.00 3.448±0.00 0.926±0.00 1.472±0.00 2.552±0.39 4.238±0.00
ENST00000519940 N/A N/A 0.986±0.00 N/A 4.934±0.00 N/A N/A N/A 2.362±0.00 7.750±0.00 N/A N/A N/A N/A
ENST00000520007 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.522±0.00 N/A N/A N/A
ENST00000520153 5.399±0.00 N/A N/A N/A 4.123±0.00 4.199±0.00 N/A N/A N/A 7.085±0.00 1.817±0.00 N/A 3.299±0.06 5.047±0.00
ENST00000520753 N/A N/A N/A 0.599±0.00 N/A N/A N/A N/A 1.405±0.00 N/A N/A 3.378±0.00 N/A N/A
ENST00000521613 N/A N/A N/A 1.151±0.00 N/A N/A N/A N/A N/A N/A 2.492±0.00 N/A N/A N/A
ENST00000522051 N/A 4.556±0.00 0.900±0.00 N/A 3.969±0.00 N/A 1.556±0.18 0.923±0.00 1.030±0.00 3.976±0.00 1.053±0.00 1.284±0.36 N/A 1.094±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0032089 IPI NACHT domain binding
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0072559 IDA NLRP3 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088074 caspase recruitment domain family, member 8 protein_coding Danio_rerio
ENSDARG00000088236 caspase recruitment domain family, member 8 protein_coding Danio_rerio
ENSDARG00000094305 caspase recruitment domain family, member 8 protein_coding Danio_rerio
ENSDARG00000096064 caspase recruitment domain family, member 8 protein_coding Danio_rerio
ENSDARG00000096067 caspase recruitment domain family, member 8 protein_coding Danio_rerio

Loading