C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105810 CDK6 9606 - 7:92604921-92836594 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265734 CDK6-001 92604921-92833917 protein_coding
  ENST00000424848 CDK6-002 92615140-92836594 protein_coding
  ENST00000467166 CDK6-003 92614714-92618277 retained_intron
  ENST00000473078 CDK6-005 92671235-92725710 retained_intron
  ENST00000491250 CDK6-004 92833403-92835297 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265734ENST00000424848
Transcript ID Adipose Bladder Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265734 1.152±0.00 0.551±0.00 1.005±0.09 0.374±0.00 2.194±1.06 2.600±2.03 2.771±1.17 0.274±0.12 6.597±3.66 1.453±0.00 2.446±0.00
ENST00000424848 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.937±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0001726 IDA ruffle
GO:0001954 IDA positive regulation of cell-matrix adhesion
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0003323 IDA type B pancreatic cell development
GO:0004672 IEA protein kinase activity
GO:0004693 IDA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0007050 TAS cell cycle arrest
GO:0007219 IEA Notch signaling pathway
GO:0008285 TAS negative regulation of cell proliferation
GO:0009615 IEP response to virus
GO:0010468 IDA regulation of gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0014002 ISS astrocyte development
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0021542 ISS dentate gyrus development
GO:0021670 ISS lateral ventricle development
GO:0030097 IEA hemopoiesis
GO:0030332 IPI cyclin binding
GO:0033077 IEA T cell differentiation in thymus
GO:0042063 IMP gliogenesis
GO:0043697 IMP cell dedifferentiation
GO:0045596 TAS negative regulation of cell differentiation
GO:0045638 IDA negative regulation of myeloid cell differentiation
GO:0045646 IMP regulation of erythrocyte differentiation
GO:0045668 IDA negative regulation of osteoblast differentiation
GO:0045786 IDA negative regulation of cell cycle
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048699 ISS generation of neurons
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051301 IEA cell division
GO:0060218 IEA hematopoietic stem cell differentiation
GO:2000145 ISS regulation of cell motility
GO:2000773 IDA negative regulation of cellular senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070228 cdk6 cyclin-dependent kinase 6 protein_coding Danio_rerio
ENSMUSG00000040274 Cdk6 cyclin-dependent kinase 6 protein_coding Mus_musculus

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