C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108953 YWHAE 9606 - 17:1344272-1400378 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264335 YWHAE-001 1344272-1400378 protein_coding
  ENST00000466227 YWHAE-002 1344539-1365058 nonsense_mediated_decay
  ENST00000469398 YWHAE-005 1361671-1400151 retained_intron
  ENST00000486241 YWHAE-006 1361681-1400209 retained_intron
  ENST00000489287 YWHAE-004 1364748-1400200 retained_intron
  ENST00000496706 YWHAE-007 1345155-1361294 protein_coding
  ENST00000498643 YWHAE-003 1399044-1400135 processed_transcript
  ENST00000571732 YWHAE-014 1344540-1400220 protein_coding
  ENST00000572108 YWHAE-011 1398878-1399589 processed_transcript
  ENST00000573026 YWHAE-013 1344855-1400181 protein_coding
  ENST00000573196 YWHAE-010 1345258-1400206 nonsense_mediated_decay
  ENST00000575977 YWHAE-012 1345328-1400214 protein_coding
  ENST00000576854 YWHAE-009 1398833-1400206 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264335ENST00000466227ENST00000489287ENST00000496706ENST00000571732ENST00000573196ENST00000575977
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264335 N/A N/A 17.132±0.00 76.840±0.00 15.866±0.00 10.633±0.00 11.151±0.00 17.819±0.00 20.072±0.00 16.183±0.00 10.650±0.00 43.616±23.53 61.585±17.80 N/A
ENST00000466227 N/A N/A N/A N/A N/A N/A N/A N/A 23.144±0.00 N/A N/A N/A N/A N/A
ENST00000489287 N/A N/A 24.621±0.00 51.004±0.00 17.994±0.00 33.618±0.00 16.919±0.00 N/A 21.239±0.00 13.786±0.00 31.012±0.00 21.215±0.00 106.307±0.00 94.270±0.00
ENST00000496706 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 21.604±0.00 N/A N/A N/A
ENST00000571732 213.903±0.00 130.949±0.00 N/A 438.877±0.00 100.482±94.65 97.377±84.33 74.103±0.00 91.548±85.24 72.435±0.00 117.965±112.04 33.886±29.97 50.646±30.46 126.495±22.11 217.180±31.96
ENST00000573196 N/A N/A N/A N/A 19.690±0.00 N/A N/A 22.502±0.00 N/A N/A N/A 79.106±0.00 167.367±0.00 146.537±0.00
ENST00000575977 N/A N/A 15.456±0.00 53.215±0.00 N/A N/A 10.651±0.00 20.552±0.00 29.268±0.00 15.759±0.00 15.646±0.00 19.878±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0001764 IEA neuron migration
GO:0003064 NAS regulation of heart rate by hormone
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005871 IEA kinesin complex
GO:0005925 IDA focal adhesion
GO:0006605 IEA protein targeting
GO:0006915 TAS apoptotic process
GO:0015459 IDA potassium channel regulator activity
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0021762 IEP substantia nigra development
GO:0021766 IEA hippocampus development
GO:0021987 IEA cerebral cortex development
GO:0023026 IDA MHC class II protein complex binding
GO:0030424 IEA axon
GO:0030659 TAS cytoplasmic vesicle membrane
GO:0032403 IEA protein complex binding
GO:0035308 IEA negative regulation of protein dephosphorylation
GO:0035329 TAS hippo signaling
GO:0035556 TAS intracellular signal transduction
GO:0042826 IPI histone deacetylase binding
GO:0043281 TAS regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044325 IPI ion channel binding
GO:0044822 IDA poly(A) RNA binding
GO:0046982 IPI protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050815 IPI phosphoserine binding
GO:0051219 IPI phosphoprotein binding
GO:0060306 IDA regulation of membrane repolarization
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0086013 IC membrane repolarization during cardiac muscle cell action potential
GO:0086091 IC regulation of heart rate by cardiac conduction
GO:0097190 TAS apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity
GO:1902309 IDA negative regulation of peptidyl-serine dephosphorylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006399 ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 protein_coding Danio_rerio
ENSDARG00000017014 ywhae2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 protein_coding Danio_rerio
ENSMUSG00000020849 Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide protein_coding Mus_musculus

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