C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: amphiregulin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109321 AREG 9606 + 4:74445134-74455009 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000395748 AREG-001 74445134-74455009 protein_coding
  ENST00000502307 AREG-002 74445302-74455005 protein_coding
  ENST00000511560 AREG-003 74448639-74450532 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000395748ENST00000502307ENST00000511560
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000395748 32.747±0.00 1.623±0.00 0.248±0.00 2.025±0.99 2.622±2.55 5.970±5.63 0.558±0.00 0.222±0.16 8.233±0.00 50.809±0.00 17.267±14.63 76.801±20.57 5.610±1.02
ENST00000502307 N/A N/A 0.035±0.00 N/A N/A N/A N/A 0.276±0.00 0.497±0.00 0.541±0.00 N/A N/A N/A
ENST00000511560 N/A N/A 0.044±0.00 N/A N/A 0.079±0.00 N/A 0.058±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000364 CIL_000364_0001 CGP 4:74365143-74455009
CIL_00036A CIL_00036A_0001 CGP 4:74445134-74794686

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005125 IEA cytokine activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005615 IDA extracellular space
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0008083 IEA growth factor activity
GO:0008283 TAS cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0014009 IEA glial cell proliferation
GO:0014070 IEA response to organic cyclic compound
GO:0016021 IEA integral component of membrane
GO:0031175 IEA neuron projection development
GO:0032355 IEA response to estradiol
GO:0042327 IEA positive regulation of phosphorylation
GO:0042542 IEA response to hydrogen peroxide
GO:0043434 IEA response to peptide hormone
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045740 IMP positive regulation of DNA replication
GO:0051384 IEA response to glucocorticoid
GO:0051591 IEA response to cAMP
GO:0060598 IEA dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744 IEA mammary gland branching involved in thelarche
GO:0060749 IEA mammary gland alveolus development
GO:0060750 IEA epithelial cell proliferation involved in mammary gland duct elongation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076853 AREG amphiregulin protein_coding Danio_rerio
ENSMUSG00000029378 Areg amphiregulin protein_coding Mus_musculus

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