C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109471 IL2 9606 - 4:122451470-122456725 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000226730 IL2-001 122451470-122456725 protein_coding
  ENST00000477645 IL2-002 122451718-122456440 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonLungOvaryENST00000226730ENST00000477645
Transcript ID Adrenal Breast Colon Lung Ovary
ENST00000226730 0.008±0.00 0.099±0.00 N/A N/A 0.023±0.00
ENST00000477645 N/A 0.088±0.00 0.157±0.09 0.052±0.00 0.041±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007AE CIL_0007AE_0001 CGP 4:122378966-122456725
CIL_0007AF CIL_0007AF_0001 CGP 4:122451470-122621069

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002903 IDA negative regulation of B cell apoptotic process
GO:0005125 IDA cytokine activity
GO:0005134 TAS:IEA interleukin-2 receptor binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 TAS extracellular space
GO:0006955 TAS:IEA immune response
GO:0007155 TAS cell adhesion
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007205 IEA protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0008083 TAS:IEA growth factor activity
GO:0008284 TAS positive regulation of cell proliferation
GO:0019209 TAS kinase activator activity
GO:0030101 TAS natural killer cell activation
GO:0030217 TAS T cell differentiation
GO:0030246 IEA carbohydrate binding
GO:0030307 TAS positive regulation of cell growth
GO:0030890 IDA positive regulation of B cell proliferation
GO:0031851 IEA kappa-type opioid receptor binding
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032740 IDA positive regulation of interleukin-17 production
GO:0034105 IC positive regulation of tissue remodeling
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 TAS negative regulation of apoptotic process
GO:0043208 IEA glycosphingolipid binding
GO:0045582 IEA positive regulation of T cell differentiation
GO:0045591 IEA positive regulation of regulatory T cell differentiation
GO:0045822 IEA negative regulation of heart contraction
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046013 IEA regulation of T cell homeostatic proliferation
GO:0048304 IEA positive regulation of isotype switching to IgG isotypes
GO:0050672 IEA negative regulation of lymphocyte proliferation
GO:0050728 IEA negative regulation of inflammatory response
GO:0050729 IC positive regulation of inflammatory response
GO:0051024 IEA positive regulation of immunoglobulin secretion
GO:0060999 IEA positive regulation of dendritic spine development
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000027720 Il2 interleukin 2 protein_coding Mus_musculus

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