C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hemopexin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110169 HPX 9606 - 11:6431049-6442617 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265983 HPX-001 6431049-6441064 protein_coding
  ENST00000525057 HPX-002 6437625-6442617 processed_transcript
  ENST00000527105 HPX-012 6440486-6440739 processed_transcript
  ENST00000527556 HPX-007 6431302-6437708 retained_intron
  ENST00000528348 HPX-003 6439609-6440990 retained_intron
  ENST00000529037 HPX-009 6431395-6432319 processed_transcript
  ENST00000529775 HPX-008 6437045-6438109 retained_intron
  ENST00000533369 HPX-006 6438334-6440987 retained_intron
  ENST00000533561 HPX-004 6431906-6441066 processed_transcript
  ENST00000533856 HPX-005 6438479-6440972 retained_intron
  ENST00000534429 HPX-010 6431950-6437667 processed_transcript
  ENST00000534800 HPX-011 6440165-6440975 processed_transcript
  ENST00000615166 HPX-201 6437097-6441024 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265983ENST00000525057ENST00000527105ENST00000527556ENST00000528348ENST00000529037ENST00000529775ENST00000533369ENST00000533561ENST00000533856ENST00000534429ENST00000534800ENST00000615166
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265983 N/A 0.111±0.00 0.056±0.00 0.086±0.00 1.427±0.00 N/A N/A 222.828±222.80 2132.790±0.00 0.083±0.00 N/A 0.349±0.00 0.206±0.08 N/A
ENST00000525057 N/A N/A N/A N/A N/A N/A 0.021±0.00 N/A N/A N/A N/A N/A N/A 0.229±0.00
ENST00000527105 N/A N/A N/A N/A N/A N/A 0.671±0.00 0.608±0.00 N/A N/A N/A N/A N/A N/A
ENST00000527556 N/A N/A N/A 0.107±0.00 0.209±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.235±0.00
ENST00000528348 N/A N/A N/A 0.030±0.00 N/A N/A N/A N/A N/A N/A N/A 0.056±0.00 N/A 0.234±0.00
ENST00000529037 N/A N/A N/A 0.093±0.00 N/A 1.385±0.00 0.030±0.00 N/A N/A 0.122±0.00 N/A N/A N/A N/A
ENST00000529775 N/A N/A N/A N/A N/A N/A 0.039±0.00 N/A N/A N/A N/A N/A 0.120±0.00 0.368±0.00
ENST00000533369 N/A N/A 0.088±0.00 0.151±0.00 1.208±0.00 N/A N/A 528.067±0.00 0.169±0.00 N/A 0.381±0.00 N/A N/A N/A
ENST00000533561 N/A N/A 0.160±0.00 0.166±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000533856 N/A N/A N/A N/A N/A N/A N/A N/A 0.631±0.00 N/A N/A N/A N/A N/A
ENST00000534429 0.147±0.00 N/A N/A N/A N/A 0.388±0.00 N/A N/A N/A N/A N/A N/A 0.267±0.00 N/A
ENST00000534800 0.054±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000615166 N/A N/A N/A N/A 0.374±0.00 N/A 0.024±0.00 0.169±0.00 N/A N/A N/A 0.051±0.00 0.141±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004N8 CIL_0004N8_0001 CGP 11:6395124-6442617
CIL_0004A5 CIL_0004A5_0001 CGP 11:6431049-6474459

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002639 IEA positive regulation of immunoglobulin production
GO:0002925 IEA positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0006879 TAS cellular iron ion homeostasis
GO:0015232 TAS heme transporter activity
GO:0015886 TAS heme transport
GO:0016032 IEA viral process
GO:0020027 IEA hemoglobin metabolic process
GO:0042168 IEA heme metabolic process
GO:0042511 IEA positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0046872 IEA metal ion binding
GO:0051246 IEA regulation of protein metabolic process
GO:0060332 IEA positive regulation of response to interferon-gamma
GO:0060335 IEA positive regulation of interferon-gamma-mediated signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071682 TAS endocytic vesicle lumen
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012609 hpx hemopexin protein_coding Danio_rerio
ENSDARG00000051912 HPX (2 of 2) hemopexin protein_coding Danio_rerio
ENSMUSG00000030895 Hpx hemopexin protein_coding Mus_musculus

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