C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 12B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113302 IL12B 9606 - 5:159314783-159330887 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000231228 IL12B-001 159314783-159330887 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastKidneyLungOvaryPlacentaTestisENST00000231228
Transcript ID Adrenal Brain Breast Kidney Lung Ovary Placenta Testis
ENST00000231228 0.017±0.00 0.004±0.00 0.034±0.00 0.013±0.00 0.102±0.08 0.009±0.00 0.014±0.00 0.031±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00087L CIL_00087L_0001 VISTA 5:158759112-159360490
CIL_0008X2 CIL_0008X2_0001 VISTA 5:158781834-159383129
CIL_0008O4 CIL_0008O4_0001 VISTA 5:158790777-159391906

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001916 ISS positive regulation of T cell mediated cytotoxicity
GO:0002230 ISS positive regulation of defense response to virus by host
GO:0002323 IEA natural killer cell activation involved in immune response
GO:0002827 ISS positive regulation of T-helper 1 type immune response
GO:0002860 IDA positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 IEA negative regulation of inflammatory response to antigenic stimulus
GO:0004896 IEA cytokine receptor activity
GO:0005125 IDA cytokine activity
GO:0005126 IEA cytokine receptor binding
GO:0005143 TAS interleukin-12 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005615 TAS extracellular space
GO:0005737 IEA cytoplasm
GO:0007050 IDA cell cycle arrest
GO:0007166 IEA cell surface receptor signaling pathway
GO:0008083 IDA growth factor activity
GO:0010224 IDA response to UV-B
GO:0010535 IDA positive regulation of activation of JAK2 kinase activity
GO:0016020 IEA membrane
GO:0016477 IDA cell migration
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019233 IEA sensory perception of pain
GO:0019953 TAS sexual reproduction
GO:0030101 IDA natural killer cell activation
GO:0032693 IMP negative regulation of interleukin-10 production
GO:0032700 IDA negative regulation of interleukin-17 production
GO:0032725 IDA positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 IDA positive regulation of interferon-gamma production
GO:0032733 IDA positive regulation of interleukin-10 production
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032740 IDA positive regulation of interleukin-17 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0032816 IDA positive regulation of natural killer cell activation
GO:0032819 IDA positive regulation of natural killer cell proliferation
GO:0032946 IMP positive regulation of mononuclear cell proliferation
GO:0034105 IC positive regulation of tissue remodeling
GO:0034393 IDA positive regulation of smooth muscle cell apoptotic process
GO:0042035 TAS regulation of cytokine biosynthetic process
GO:0042088 TAS T-helper 1 type immune response
GO:0042093 IDA T-helper cell differentiation
GO:0042095 TAS interferon-gamma biosynthetic process
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0042164 IPI interleukin-12 alpha subunit binding
GO:0042346 TAS positive regulation of NF-kappaB import into nucleus
GO:0042510 IDA regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IDA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 IDA positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042802 IPI identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0042832 IEA defense response to protozoan
GO:0043382 ISS positive regulation of memory T cell differentiation
GO:0043514 IDA interleukin-12 complex
GO:0044130 IEA negative regulation of growth of symbiont in host
GO:0045078 TAS positive regulation of interferon-gamma biosynthetic process
GO:0045519 IDA interleukin-23 receptor binding
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045785 IDA positive regulation of cell adhesion
GO:0046982 IPI protein heterodimerization activity
GO:0048662 IDA negative regulation of smooth muscle cell proliferation
GO:0050671 IDA positive regulation of lymphocyte proliferation
GO:0050729 IC positive regulation of inflammatory response
GO:0050829 IDA defense response to Gram-negative bacterium
GO:0051135 IDA positive regulation of NK T cell activation
GO:0051142 IDA positive regulation of NK T cell proliferation
GO:0051607 IEA defense response to virus
GO:0070743 IDA interleukin-23 complex
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071346 IEA cellular response to interferon-gamma
GO:2000318 ISS positive regulation of T-helper 17 type immune response
GO:2000330 ISS positive regulation of T-helper 17 cell lineage commitment

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033727 il12ba interleukin 12Ba protein_coding Danio_rerio
ENSDARG00000054542 il12bb interleukin 12B, b protein_coding Danio_rerio
ENSDARG00000069504 IL12B (3 of 3) interleukin 12B protein_coding Danio_rerio
ENSMUSG00000004296 Il12b interleukin 12b protein_coding Mus_musculus

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