C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 12b
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004296 Il12b 10090 + 11:44400063-44414033 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000102796 Il12b-001 44400063-44414033 protein_coding
  ENSMUST00000170513 Il12b-201 44400063-44414010 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaENSMUST00000102796
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta
ENSMUST00000102796 0.131±0.11 0.040±0.00 0.020±0.00 0.537±0.13 0.171±0.00 0.017±0.00 0.062±0.02 0.015±0.01 0.123±0.06 0.082±0.04 0.016±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008O4 CIL_0008O4_0002 VISTA 11:44325594-44926697
CIL_0008X2 CIL_0008X2_0002 VISTA 11:44334332-44935609
CIL_00087L CIL_00087L_0002 VISTA 11:44356475-44957869
CIL_0005EZ CIL_0005EZ_0002 CGP 11:44400063-44470498

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001916 IDA positive regulation of T cell mediated cytotoxicity
GO:0002230 IDA positive regulation of defense response to virus by host
GO:0002323 IEA natural killer cell activation involved in immune response
GO:0002827 IDA positive regulation of T-helper 1 type immune response
GO:0002860 IEA positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 IMP negative regulation of inflammatory response to antigenic stimulus
GO:0004896 IEA cytokine receptor activity
GO:0005125 IDA cytokine activity
GO:0005126 IPI cytokine receptor binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0007050 IEA cell cycle arrest
GO:0007166 IDA cell surface receptor signaling pathway
GO:0008083 IEA growth factor activity
GO:0010224 IEA response to UV-B
GO:0010535 IEA positive regulation of activation of JAK2 kinase activity
GO:0016020 IEA membrane
GO:0016477 IEA cell migration
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019233 IEA sensory perception of pain
GO:0030101 ISS natural killer cell activation
GO:0032693 IEA negative regulation of interleukin-10 production
GO:0032700 IEA negative regulation of interleukin-17 production
GO:0032725 IEA positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032733 IEA positive regulation of interleukin-10 production
GO:0032735 IEA positive regulation of interleukin-12 production
GO:0032740 IEA positive regulation of interleukin-17 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0032816 IEA positive regulation of natural killer cell activation
GO:0032819 IEA positive regulation of natural killer cell proliferation
GO:0032946 IEA positive regulation of mononuclear cell proliferation
GO:0034393 IEA positive regulation of smooth muscle cell apoptotic process
GO:0042093 ISS T-helper cell differentiation
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042104 ISS positive regulation of activated T cell proliferation
GO:0042164 IPI interleukin-12 alpha subunit binding
GO:0042510 IEA regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 IEA positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 IEA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042802 IEA identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0042832 IGI defense response to protozoan
GO:0043514 IDA interleukin-12 complex
GO:0044130 IMP negative regulation of growth of symbiont in host
GO:0045519 IEA interleukin-23 receptor binding
GO:0045672 IEA positive regulation of osteoclast differentiation
GO:0045785 IEA positive regulation of cell adhesion
GO:0046982 IEA protein heterodimerization activity
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050671 IEA positive regulation of lymphocyte proliferation
GO:0050829 IEA defense response to Gram-negative bacterium
GO:0051135 IEA positive regulation of NK T cell activation
GO:0051142 IEA positive regulation of NK T cell proliferation
GO:0051607 IDA defense response to virus
GO:0070743 IEA interleukin-23 complex
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071346 IDA cellular response to interferon-gamma

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033727 il12ba interleukin 12Ba protein_coding Danio_rerio
ENSDARG00000054542 il12bb interleukin 12B, b protein_coding Danio_rerio
ENSDARG00000069504 IL12B (3 of 3) interleukin 12B protein_coding Danio_rerio
ENSG00000113302 IL12B interleukin 12B protein_coding Homo_sapiens

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