C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 2, catalytic subunit, alpha isozyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113575 PPP2CA 9606 - 5:134194334-134226142 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000231504 PPP2CA-007 134203525-134226073 processed_transcript
  ENST00000472253 PPP2CA-004 134197636-134199450 retained_intron
  ENST00000481195 PPP2CA-001 134194334-134226142 protein_coding
  ENST00000495833 PPP2CA-003 134200974-134202485 retained_intron
  ENST00000522385 PPP2CA-005 134200988-134225554 protein_coding
  ENST00000523082 PPP2CA-006 134201859-134224393 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000481195
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000481195 14.532±0.00 16.372±0.00 5.003±0.00 27.788±8.16 9.574±3.05 10.292±4.08 12.308±8.25 11.782±7.24 5.161±1.80 14.767±3.26 7.997±2.89 14.618±4.35 23.661±1.55 22.355±1.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089W CIL_00089W_0001 VISTA 5:134136326-134739629
CIL_00062V CIL_00062V_0002 CGP 5:134167170-134226142

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000159 TAS protein phosphatase type 2A complex
GO:0000184 TAS nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 NAS inactivation of MAPK activity
GO:0000278 TAS mitotic cell cycle
GO:0000775 IEA chromosome, centromeric region
GO:0001932 IEA regulation of protein phosphorylation
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004722 IEA protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005634 NAS nucleus
GO:0005737 IEA cytoplasm
GO:0005739 NAS mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006275 NAS regulation of DNA replication
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006470 TAS protein dephosphorylation
GO:0006672 NAS ceramide metabolic process
GO:0006915 TAS apoptotic process
GO:0007084 TAS mitotic nuclear envelope reassembly
GO:0007498 IEA mesoderm development
GO:0008022 IEA protein C-terminus binding
GO:0008380 NAS RNA splicing
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010033 NAS response to organic substance
GO:0010467 TAS gene expression
GO:0010469 IEA regulation of receptor activity
GO:0010719 IMP negative regulation of epithelial to mesenchymal transition
GO:0015630 NAS microtubule cytoskeleton
GO:0016020 NAS membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016311 IEA dephosphorylation
GO:0016787 IEA hydrolase activity
GO:0019932 NAS second-messenger-mediated signaling
GO:0030111 NAS regulation of Wnt signaling pathway
GO:0030155 NAS regulation of cell adhesion
GO:0030308 NAS negative regulation of cell growth
GO:0031952 IEA regulation of protein autophosphorylation
GO:0040008 NAS regulation of growth
GO:0042176 IEA regulation of protein catabolic process
GO:0042518 NAS negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595 NAS regulation of cell differentiation
GO:0046872 IEA metal ion binding
GO:0046983 IEA protein dimerization activity
GO:0050811 IEA GABA receptor binding
GO:0051321 IEA meiotic cell cycle
GO:0070062 IDA extracellular vesicular exosome
GO:0070208 IEA protein heterotrimerization
GO:0071902 IMP positive regulation of protein serine/threonine kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030224 ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform protein_coding Danio_rerio
ENSDARG00000053404 PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme protein_coding Danio_rerio
ENSMUSG00000020349 Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform protein_coding Mus_musculus

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