C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114353 GNAI2 9606 + 3:50226292-50259355 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000266027 GNAI2-201 50230776-50259339 protein_coding
  ENST00000313601 GNAI2-001 50235952-50259355 protein_coding
  ENST00000422163 GNAI2-003 50226292-50258898 protein_coding
  ENST00000440628 GNAI2-009 50238112-50258751 protein_coding
  ENST00000441156 GNAI2-005 50236204-50259354 nonsense_mediated_decay
  ENST00000446079 GNAI2-004 50226737-50258898 nonsense_mediated_decay
  ENST00000451956 GNAI2-002 50246894-50258697 protein_coding
  ENST00000468422 GNAI2-010 50253154-50256691 retained_intron
  ENST00000480090 GNAI2-008 50230810-50235290 processed_transcript
  ENST00000490122 GNAI2-006 50251409-50258893 retained_intron
  ENST00000491100 GNAI2-007 50229065-50259345 processed_transcript
  ENST00000492383 GNAI2-011 50256283-50258166 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000313601ENST00000440628ENST00000441156ENST00000451956ENST00000490122ENST00000491100
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000313601 256.736±0.00 114.335±0.00 3.180±0.00 41.860±25.89 50.156±41.01 51.342±44.35 20.804±11.39 27.835±20.73 19.652±1.01 134.819±110.04 27.823±0.00 85.502±62.71 209.456±9.03 59.441±10.77
ENST00000440628 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 56.938±0.00 N/A N/A
ENST00000441156 50.159±0.00 104.906±0.00 N/A 27.403±0.00 N/A 62.667±0.00 8.646±0.00 16.721±14.96 11.353±0.00 110.261±0.00 8.538±7.30 32.242±0.00 100.453±21.88 40.995±0.00
ENST00000451956 N/A N/A 1.201±0.00 N/A N/A 3.445±0.00 N/A N/A N/A N/A 2.805±0.00 5.189±0.00 118.301±0.00 57.969±0.00
ENST00000490122 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.975±0.00 N/A N/A N/A
ENST00000491100 N/A N/A 0.544±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0001664 IBA G-protein coupled receptor binding
GO:0001973 IBA adenosine receptor signaling pathway
GO:0003924 IBA:IEA GTPase activity
GO:0004871 IBA:IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 IEA cytosol
GO:0005834 IBA heterotrimeric G-protein complex
GO:0005886 IDA plasma membrane
GO:0006184 IEA GTP catabolic process
GO:0007049 IEA cell cycle
GO:0007165 TAS:IEA signal transduction
GO:0007186 TAS:IEA G-protein coupled receptor signaling pathway
GO:0007193 IBA adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 TAS negative regulation of adenylate cyclase activity
GO:0007213 IEA G-protein coupled acetylcholine receptor signaling pathway
GO:0007214 IBA gamma-aminobutyric acid signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007584 TAS response to nutrient
GO:0007596 TAS blood coagulation
GO:0008283 IEA cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0016020 IDA membrane
GO:0019001 IEA guanyl nucleotide binding
GO:0030168 TAS platelet activation
GO:0030496 IDA midbody
GO:0031683 IBA:IEA G-protein beta/gamma-subunit complex binding
GO:0031982 IDA vesicle
GO:0035556 IEA intracellular signal transduction
GO:0045121 IEA membrane raft
GO:0046872 IEA metal ion binding
GO:0050805 IEA negative regulation of synaptic transmission
GO:0051301 IMP cell division
GO:0051924 IEA regulation of calcium ion transport
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017294 gnai2b guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b protein_coding Danio_rerio
ENSDARG00000018174 gnai2a guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a protein_coding Danio_rerio
ENSMUSG00000032562 Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 protein_coding Mus_musculus

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