C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115738 ID2 9606 + 2:8678845-8684453 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000234091 ID2-001 8678845-8684453 protein_coding
  ENST00000331129 ID2-002 8682056-8683007 protein_coding
  ENST00000396290 ID2-201 8681983-8684451 protein_coding
  ENST00000472142 ID2-003 8682780-8684031 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000331129ENST00000396290ENST00000472142
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000331129 N/A 21.870±0.00 N/A N/A N/A N/A 5.805±0.00 25.923±0.00 20.521±15.49 27.833±0.00 6.043±0.00 19.120±13.59 26.675±0.00 7.111±0.00
ENST00000396290 10.639±0.00 25.124±0.00 4.805±0.00 26.320±7.94 13.318±4.40 23.351±13.13 5.272±3.65 36.911±8.72 25.841±17.01 16.883±6.57 2.255±1.73 55.075±49.99 15.071±8.01 27.574±0.00
ENST00000472142 5.099±0.00 N/A 2.722±0.00 N/A N/A N/A 2.824±1.83 N/A 16.821±0.00 13.094±0.00 2.022±0.00 8.063±1.82 7.336±0.00 2.981±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00099S CIL_00099S_0001 VISTA 2:8341264-8943461
CIL_0002BL CIL_0002BL_0002 CGP 2:8678845-8837630

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000785 IEA chromatin
GO:0001656 IEA metanephros development
GO:0001779 IEA natural killer cell differentiation
GO:0002521 IEA leukocyte differentiation
GO:0003149 IEA membranous septum morphogenesis
GO:0003166 IEA bundle of His development
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0007275 TAS multicellular organismal development
GO:0007507 IEA heart development
GO:0007623 IEA circadian rhythm
GO:0008284 IEA positive regulation of cell proliferation
GO:0009649 IEA entrainment of circadian clock
GO:0010628 ISS positive regulation of gene expression
GO:0010629 ISS negative regulation of gene expression
GO:0014003 IEA oligodendrocyte development
GO:0019216 ISS regulation of lipid metabolic process
GO:0021772 IEA olfactory bulb development
GO:0032922 ISS circadian regulation of gene expression
GO:0033598 ISS mammary gland epithelial cell proliferation
GO:0042752 ISS regulation of circadian rhythm
GO:0043153 ISS entrainment of circadian clock by photoperiod
GO:0043234 ISS protein complex
GO:0043353 IEA enucleate erythrocyte differentiation
GO:0043392 IEA negative regulation of DNA binding
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044325 IPI ion channel binding
GO:0045475 ISS locomotor rhythm
GO:0045578 IEA negative regulation of B cell differentiation
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045777 ISS positive regulation of blood pressure
GO:0045787 IEA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046983 IEA protein dimerization activity
GO:0048468 IEA cell development
GO:0048469 IEA cell maturation
GO:0048541 IEA Peyer's patch development
GO:0048557 ISS embryonic digestive tract morphogenesis
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0048663 ISS neuron fate commitment
GO:0048711 IEA positive regulation of astrocyte differentiation
GO:0048715 IEA negative regulation of oligodendrocyte differentiation
GO:0060612 IEA adipose tissue development
GO:0060749 ISS mammary gland alveolus development
GO:0061030 ISS epithelial cell differentiation involved in mammary gland alveolus development
GO:0061031 ISS endodermal digestive tract morphogenesis
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0071285 IEA cellular response to lithium ion
GO:0071931 IC positive regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090398 ISS cellular senescence
GO:2000045 IMP regulation of G1/S transition of mitotic cell cycle
GO:2000178 ISS negative regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029544 id2b inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b protein_coding Danio_rerio
ENSDARG00000055283 id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a protein_coding Danio_rerio
ENSMUSG00000020644 Id2 inhibitor of DNA binding 2 protein_coding Mus_musculus

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