C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: AP2 associated kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115977 AAK1 9606 - 2:69457995-69674349 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339092 AAK1-201 69457995-69643845 protein_coding
  ENST00000406297 AAK1-002 69481056-69643717 protein_coding
  ENST00000409068 AAK1-011 69461400-69643654 protein_coding
  ENST00000409085 AAK1-001 69467787-69643717 protein_coding
  ENST00000461002 AAK1-007 69643085-69674349 processed_transcript
  ENST00000470281 AAK1-006 69531717-69544509 processed_transcript
  ENST00000471775 AAK1-010 69642906-69643950 processed_transcript
  ENST00000489327 AAK1-005 69478456-69509493 retained_intron
  ENST00000492192 AAK1-009 69643093-69643845 processed_transcript
  ENST00000495239 AAK1-008 69642877-69643960 processed_transcript
  ENST00000495836 AAK1-003 69544239-69643717 retained_intron
  ENST00000606389 AAK1-012 69457997-69509280 protein_coding
  ENST00000623317 AAK1-013 69465846-69509280 protein_coding
  ENST00000624900 AAK1-014 69499869-69509262 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000339092ENST00000406297ENST00000409068ENST00000409085ENST00000606389
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000339092 0.359±0.00 N/A 1.246±0.00 N/A N/A N/A 0.122±0.00 N/A 0.495±0.33 0.170±0.00 0.737±0.00 N/A 0.290±0.00
ENST00000406297 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.868±0.00 N/A N/A N/A
ENST00000409068 N/A N/A N/A N/A N/A 9.303±0.00 N/A 4.315±0.00 N/A N/A N/A N/A N/A
ENST00000409085 N/A N/A 7.730±1.35 N/A N/A 1.118±0.22 N/A N/A N/A N/A N/A N/A N/A
ENST00000606389 N/A 2.569±0.00 4.000±0.00 2.146±0.00 1.443±0.44 8.994±0.00 2.605±1.60 N/A 1.600±0.00 1.675±0.00 1.448±0.60 1.740±1.27 2.125±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000YR CIL_0000YR_0002 CGP 2:69457995-69826464

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005112 IDA Notch binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005905 IEA coated pit
GO:0006468 IEA protein phosphorylation
GO:0006897 IEA endocytosis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019897 ISS extrinsic component of plasma membrane
GO:0030136 ISS clathrin-coated vesicle
GO:0031252 ISS cell leading edge
GO:0032880 IDA regulation of protein localization
GO:0035612 IDA AP-2 adaptor complex binding
GO:0043195 ISS terminal bouton
GO:0045747 IDA positive regulation of Notch signaling pathway
GO:0046777 ISS protein autophosphorylation
GO:0050821 IDA protein stabilization
GO:2000369 IMP regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011855 AAK1 (1 of 2) AP2 associated kinase 1 protein_coding Danio_rerio
ENSDARG00000077686 aak1 AP2 associated kinase 1 protein_coding Danio_rerio
ENSMUSG00000057230 Aak1 AP2 associated kinase 1 protein_coding Mus_musculus

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