C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cystathionine gamma-lyase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116761 CTH 9606 + 1:70411218-70439851 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346806 CTH-002 70411383-70439204 protein_coding
  ENST00000370938 CTH-001 70411272-70439570 protein_coding
  ENST00000411986 CTH-201 70411218-70439851 protein_coding
  ENST00000464926 CTH-003 70411272-70430394 processed_transcript
  ENST00000482383 CTH-004 70434851-70439232 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000346806ENST00000370938ENST00000411986ENST00000464926ENST00000482383
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000346806 N/A N/A N/A N/A 0.504±0.30 N/A 0.122±0.00 N/A N/A 0.511±0.00 0.589±0.00 N/A N/A N/A
ENST00000370938 0.737±0.00 N/A 0.654±0.00 0.596±0.21 0.186±0.00 0.524±0.11 0.217±0.00 12.469±10.52 19.646±0.00 0.761±0.00 N/A 2.190±1.41 0.304±0.23 0.916±0.37
ENST00000411986 0.375±0.00 0.216±0.00 0.361±0.00 0.341±0.12 0.293±0.00 0.303±0.00 0.224±0.00 1.450±0.00 N/A 0.177±0.00 0.140±0.00 0.295±0.00 N/A 0.367±0.00
ENST00000464926 0.651±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.708±0.00 0.245±0.00 0.455±0.00 N/A N/A
ENST00000482383 N/A 0.320±0.00 1.056±0.00 1.931±0.00 0.657±0.00 N/A 0.274±0.00 N/A N/A N/A 0.342±0.00 N/A N/A 0.689±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0000098 TAS sulfur amino acid catabolic process
GO:0004123 IDA cystathionine gamma-lyase activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006534 TAS cysteine metabolic process
GO:0008152 IEA metabolic process
GO:0009058 IEA biosynthetic process
GO:0016846 TAS carbon-sulfur lyase activity
GO:0018272 IDA protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344 IEA cysteine biosynthetic process
GO:0019346 TAS transsulfuration
GO:0030170 IDA:IEA pyridoxal phosphate binding
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281 TAS small molecule metabolic process
GO:0044524 IMP protein sulfhydration
GO:0044540 IMP L-cystine L-cysteine-lyase (deaminating)
GO:0047982 TAS homocysteine desulfhydrase activity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051289 IPI protein homotetramerization
GO:0070062 IDA extracellular vesicular exosome
GO:0070814 IDA hydrogen sulfide biosynthetic process
GO:0080146 TAS L-cysteine desulfhydrase activity
GO:2001234 IEA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032206 cthl cystathionase (cystathionine gamma-lyase), like protein_coding Danio_rerio
ENSDARG00000074301 cth cystathionase (cystathionine gamma-lyase) protein_coding Danio_rerio
ENSMUSG00000028179 Cth cystathionase (cystathionine gamma-lyase) protein_coding Mus_musculus

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