C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cystathionase (cystathionine gamma-lyase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028179 Cth 10090 - 3:157894248-157925077 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000118539 Cth-001 157894248-157925077 protein_coding
  ENSMUST00000125028 Cth-002 157919700-157925051 retained_intron
  ENSMUST00000129805 Cth-003 157894423-157897712 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000118539ENSMUST00000125028ENSMUST00000129805
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000118539 7.401±1.25 6.058±0.37 2.072±0.61 1.083±0.50 4.184±0.62 21.847±2.88 0.619±0.18 93.224±15.63 193.405±160.97 2.727±0.33 0.974±0.31 2.303±0.67 1.627±0.73 0.724±0.46
ENSMUST00000125028 N/A 18.543±6.92 N/A N/A N/A 13.337±1.07 N/A N/A 170.369±15.45 1.894±0.00 N/A 2.788±1.48 N/A 0.447±0.00
ENSMUST00000129805 N/A N/A N/A 1.317±0.00 N/A N/A 0.327±0.13 N/A N/A N/A 1.217±0.00 1.211±0.52 2.783±0.01 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000WV CIL_0000WV_0002 CGP 3:157566892-157925077

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004123 ISS cystathionine gamma-lyase activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0018272 ISS protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344 ISS cysteine biosynthetic process
GO:0030170 ISS pyridoxal phosphate binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524 IMP protein sulfhydration
GO:0044540 IMP L-cystine L-cysteine-lyase (deaminating)
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051289 IEA protein homotetramerization
GO:0070062 IEA extracellular vesicular exosome
GO:0070814 ISS hydrogen sulfide biosynthetic process
GO:0080146 IEA L-cysteine desulfhydrase activity
GO:2001234 IMP negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032206 cthl cystathionase (cystathionine gamma-lyase), like protein_coding Danio_rerio
ENSDARG00000074301 cth cystathionase (cystathionine gamma-lyase) protein_coding Danio_rerio
ENSG00000116761 CTH cystathionine gamma-lyase protein_coding Homo_sapiens

Loading