C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endothelin converting enzyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117298 ECE1 9606 - 1:21217247-21345504 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264205 ECE1-006 21219937-21290257 protein_coding
  ENST00000357071 ECE1-005 21218584-21279549 protein_coding
  ENST00000374893 ECE1-002 21219859-21290489 protein_coding
  ENST00000415912 ECE1-001 21217247-21345504 protein_coding
  ENST00000436918 ECE1-008 21219894-21290464 protein_coding
  ENST00000463334 ECE1-004 21272835-21345137 processed_transcript
  ENST00000470394 ECE1-003 21233570-21238350 retained_intron
  ENST00000473505 ECE1-007 21260313-21280069 protein_coding
  ENST00000481130 ECE1-010 21272746-21298999 protein_coding
  ENST00000526194 ECE1-009 21233105-21290463 retained_intron
  ENST00000527991 ECE1-011 21272832-21294424 protein_coding
  ENST00000528294 ECE1-012 21238149-21256717 processed_transcript
  ENST00000531334 ECE1-013 21219814-21222081 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264205ENST00000357071ENST00000374893ENST00000415912ENST00000436918
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264205 N/A N/A 2.255±0.00 N/A N/A 3.595±0.00 N/A N/A N/A 3.657±0.00 4.114±0.00 N/A N/A N/A
ENST00000357071 N/A N/A N/A N/A 2.129±0.00 1.121±0.00 N/A 1.120±0.00 N/A 2.475±0.00 N/A 3.737±0.00 N/A N/A
ENST00000374893 64.102±0.00 N/A N/A 9.648±0.00 6.471±4.42 13.366±0.00 6.665±0.00 N/A 7.825±0.00 25.517±0.00 N/A 15.117±3.12 N/A 9.860±0.00
ENST00000415912 56.131±0.00 16.966±0.00 0.429±0.00 7.781±0.00 20.987±0.00 19.123±0.00 6.347±5.34 9.123±0.00 7.747±4.31 43.183±0.00 4.655±0.00 23.419±15.45 23.415±7.42 9.938±5.84
ENST00000436918 N/A N/A 1.099±0.00 1.337±0.00 4.444±0.00 N/A 2.841±0.00 8.237±0.00 N/A 4.384±0.00 N/A 21.574±0.00 27.445±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002W8 CIL_0002W8_0002 CGP 1:20806292-21345504

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001921 IMP positive regulation of receptor recycling
GO:0003100 IC regulation of systemic arterial blood pressure by endothelin
GO:0004175 IDA endopeptidase activity
GO:0004222 IEA:ISS metalloendopeptidase activity
GO:0005765 IDA lysosomal membrane
GO:0005768 IDA endosome
GO:0005769 IDA early endosome
GO:0005886 IDA plasma membrane
GO:0006508 IEA proteolysis
GO:0007507 IMP heart development
GO:0009897 IDA external side of plasma membrane
GO:0010814 IDA substance P catabolic process
GO:0010815 IDA bradykinin catabolic process
GO:0010816 IDA calcitonin catabolic process
GO:0016020 IDA membrane
GO:0016021 IDA integral component of membrane
GO:0016485 IEA:IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0017046 IC peptide hormone binding
GO:0019229 IC regulation of vasoconstriction
GO:0031302 TAS intrinsic component of endosome membrane
GO:0031982 ISS vesicle
GO:0033093 IDA Weibel-Palade body
GO:0034959 IDA endothelin maturation
GO:0042447 IDA hormone catabolic process
GO:0042733 IMP embryonic digit morphogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043583 IMP ear development
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0060037 IEA pharyngeal system development
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061737 ece1 endothelin converting enzyme 1 protein_coding Danio_rerio
ENSMUSG00000057530 Ece1 endothelin converting enzyme 1 protein_coding Mus_musculus

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