C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fas ligand (TNF superfamily, member 6)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117560 FASLG 9606 + 1:172659018-172666874 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340030 FASLG-201 172659144-172666075 protein_coding
  ENST00000367721 FASLG-001 172659018-172666874 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000340030ENST00000367721
Transcript ID Bladder Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000340030 N/A N/A N/A 0.008±0.00 N/A 0.123±0.00 0.834±0.00 N/A N/A 0.045±0.00
ENST00000367721 0.180±0.00 0.085±0.02 0.210±0.20 0.010±0.00 0.244±0.22 0.202±0.00 1.053±0.00 0.109±0.01 0.134±0.06 0.064±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0005102 TAS receptor binding
GO:0005123 IEA death receptor binding
GO:0005125 IEA cytokine activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005764 IEA lysosome
GO:0005887 TAS integral component of plasma membrane
GO:0005901 IEA caveola
GO:0006351 IEA transcription, DNA-templated
GO:0006915 TAS apoptotic process
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925 IEA inflammatory cell apoptotic process
GO:0006955 IEA immune response
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0008284 IEA positive regulation of cell proliferation
GO:0008625 IDA extrinsic apoptotic signaling pathway via death domain receptors
GO:0009897 IEA external side of plasma membrane
GO:0016020 IEA membrane
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016525 IDA negative regulation of angiogenesis
GO:0030644 IEA cellular chloride ion homeostasis
GO:0032496 IEA response to lipopolysaccharide
GO:0043065 IDA positive regulation of apoptotic process
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045121 IEA membrane raft
GO:0045742 IEA positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666 IEA retinal cell programmed cell death
GO:0048388 IEA endosomal lumen acidification
GO:0048471 IEA perinuclear region of cytoplasm
GO:0070062 IDA extracellular vesicular exosome
GO:0070231 IDA T cell apoptotic process
GO:0070266 IDA necroptotic process
GO:0070848 IEA response to growth factor
GO:0097190 IDA apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097527 IDA necroptotic signaling pathway
GO:2000353 IDA positive regulation of endothelial cell apoptotic process
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011520 faslg Fas ligand (TNF superfamily, member 6) protein_coding Danio_rerio
ENSMUSG00000000817 Fasl Fas ligand (TNF superfamily, member 6) protein_coding Mus_musculus

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