C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NIMA-related kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117650 NEK2 9606 - 1:211658657-211675630 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366998 NEK2-002 211666430-211675557 protein_coding
  ENST00000366999 NEK2-001 211662772-211675618 protein_coding
  ENST00000462283 NEK2-004 211663403-211671284 processed_transcript
  ENST00000489633 NEK2-003 211663525-211669519 processed_transcript
  ENST00000540251 NEK2-201 211658657-211675630 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000366998ENST00000366999ENST00000462283ENST00000489633ENST00000540251
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000366998 0.175±0.00 0.208±0.00 0.151±0.04 0.166±0.12 0.845±0.00 0.037±0.00 0.177±0.00 0.054±0.00 N/A N/A N/A N/A
ENST00000366999 0.046±0.00 0.132±0.00 0.155±0.00 0.037±0.00 0.463±0.00 N/A N/A 0.007±0.00 0.340±0.00 5.031±4.72 1.588±0.72 38.709±4.81
ENST00000462283 N/A N/A 0.451±0.00 N/A N/A N/A N/A N/A 0.800±0.00 N/A N/A N/A
ENST00000489633 N/A N/A N/A N/A N/A N/A N/A N/A 0.590±0.00 N/A N/A N/A
ENST00000540251 N/A N/A 0.077±0.00 0.779±0.00 0.367±0.00 N/A N/A N/A 0.153±0.00 N/A N/A 15.612±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000070 IEA mitotic sister chromatid segregation
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000776 IDA kinetochore
GO:0000794 IEA condensed nuclear chromosome
GO:0000922 IEA spindle pole
GO:0001824 IEA blastocyst development
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005874 IEA microtubule
GO:0006468 IDA:IEA protein phosphorylation
GO:0007059 IDA chromosome segregation
GO:0007067 TAS mitotic nuclear division
GO:0007088 TAS regulation of mitosis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019903 IPI protein phosphatase binding
GO:0030496 IEA midbody
GO:0043234 IMP protein complex
GO:0043392 IEA negative regulation of DNA binding
GO:0045171 IDA intercellular bridge
GO:0046602 TAS regulation of mitotic centrosome separation
GO:0046777 IMP protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0051225 TAS spindle assembly
GO:0051299 IDA centrosome separation
GO:0051321 IEA meiotic cell cycle
GO:0051988 IMP regulation of attachment of spindle microtubules to kinetochore
GO:0090307 IEA spindle assembly involved in mitosis
GO:1903126 IMP negative regulation of centriole-centriole cohesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005619 nek2 NIMA (never in mitosis gene a)-related kinase 2 protein_coding Danio_rerio
ENSMUSG00000026622 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 protein_coding Mus_musculus

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